Innovative Therapeutic Strategies Targeting the Network Architecture of Glioblastoma

被引：0
作者：
Beichert, Julius [1 ]
Hoffmann, Dirk C. [2 ,3 ,4 ]
Winkler, Frank [2 ,3 ,4 ]
Ratliff, Miriam [1 ,2 ]
机构：
[1] Heidelberg Univ, Univ Hosp Mannheim, Dept Neurosurg, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany
[2] German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Clin Cooperat Unit Neurooncol, Heidelberg, Germany
[3] Univ Hosp Heidelberg, Neurol Clin, Heidelberg, Germany
[4] Univ Hosp Heidelberg, Natl Ctr Tumor Dis, Heidelberg, Germany
来源：
CLINICAL CANCER RESEARCH | 2025年 / 31卷 / 14期
关键词：
GLUTAMATE TRANSPORTERS; ADJUNCTIVE PERAMPANEL; CANCER NEUROSCIENCE; GLIOMA-CELLS; BRAIN-TUMORS; PHASE-III; RILUZOLE; GROWTH; SEIZURES; RELEASE;
D O I：
10.1158/1078-0432.CCR-25-0018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent discoveries concerning the network architecture of glioblastoma, including tumor microtubules and neuron-glioma synapses, have underscored critical pathways that sustain tumor growth, enhance resistance, and integrate glioblastoma with the surrounding neural environment. This review explores emerging therapeutic strategies targeting these pathways, including inhibitors of gap junctions, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, and glutamate signaling, which are currently being tested in clinical trials. By consolidating these advances, this review seeks to bridge the gap between neurobiology, cancer neuroscience, and oncology, proposing novel approaches to overcome resistance and improve patient outcomes. The insights derived from this comprehensive review hold the potential to significantly influence the future management of glioblastoma.
引用
收藏
页码：2864 / 2871
页数：8
相关论文
共 78 条
[1]   Drug repurposing for the treatment of glioblastoma multiforme [J].
Abbruzzese, Claudia ;
Matteoni, Silvia ;
Signore, Michele ;
Cardone, Luca ;
Nath, Kavindra ;
Glickson, Jerry D. ;
Paggi, Marco G. .
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2017, 36
[2]   Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE [J].
Alexander, Brian M. ;
Ba, Sujuan ;
Berger, Mitchel S. ;
Berry, Donald A. ;
Cavenee, Webster K. ;
Chang, Susan M. ;
Cloughesy, Timothy F. ;
Jiang, Tao ;
Khasraw, Mustafa ;
Li, Wenbin ;
Mittman, Robert ;
Poste, George H. ;
Wen, Patrick Y. ;
Yung, W. K. Alfred ;
Barker, Anna D. .
CLINICAL CANCER RESEARCH, 2018, 24 (04) :737-743
[3]   Emergence of scaling in random networks [J].
Barabási, AL ;
Albert, R .
SCIENCE, 1999, 286 (5439) :509-512
[4]   Riluzole Partially Rescues Age-Associated, but not LPS-Induced, Loss of Glutamate Transporters and Spatial Memory [J].
Brothers, Holly M. ;
Bardou, Isabelle ;
Hopp, Sarah C. ;
Kaercher, Roxanne M. ;
Corona, Angela W. ;
Fenn, Ashley M. ;
Godbout, Jonathan P. ;
Wenk, Gary L. .
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2013, 8 (05) :1098-1105
[5]   Glutamate release by primary brain tumors induces epileptic activity [J].
Buckingham, Susan C. ;
Campbell, Susan L. ;
Haas, Brian R. ;
Montana, Vedrana ;
Robel, Stefanie ;
Ogunrinu, Toyin ;
Sontheimer, Harald .
NATURE MEDICINE, 2011, 17 (10) :1269-U299
[6]   Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes [J].
Campbell, Susan C. ;
Munoz-Ballester, Carmen ;
Chaunsali, Lata ;
Mills, William A., III ;
Yang, Jennifer H. ;
Sontheimer, Harald ;
Robel, Stefanie .
NEUROCHEMISTRY INTERNATIONAL, 2020, 133
[7]   Riluzole elevates GLT-1 activity and levels in striatal astrocytes [J].
Carbone, Marica ;
Duty, Susan ;
Rattray, Marcus .
NEUROCHEMISTRY INTERNATIONAL, 2012, 60 (01) :31-38
[8]   Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis [J].
Cheah, B. C. ;
Vucic, S. ;
Krishnan, A. V. ;
Kiernan, M. C. .
CURRENT MEDICINAL CHEMISTRY, 2010, 17 (18) :1942-1959
[9]   New uses for old drugs [J].
Chong, Curtis R. ;
Sullivan, David J., Jr. .
NATURE, 2007, 448 (7154) :645-646
[10]   The Drug Repurposing Hub: a next-generation drug library and information resource [J].
Corsello, Steven M. ;
Bittker, Joshua A. ;
Liu, Zihan ;
Gould, Joshua ;
McCarren, Patrick ;
Hirschman, Jodi E. ;
Johnston, Stephen E. ;
Vrcic, Anita ;
Wong, Bang ;
Khan, Mariya ;
Asiedu, Jacob ;
Narayan, Rajiv ;
Mader, Christopher C. ;
Subramanian, Aravind ;
Golub, Todd R. .
NATURE MEDICINE, 2017, 23 (04) :405-+
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