Total Synthesis and Structural Revision of (-)-Sodagnitin E

被引：0

作者：

Schoch, Philipp ^{[1
]}

Gaich, Tanja ^{[1
]}

机构：

[1] Univ Konstanz, Dept Chem, Univ Str 10, D-78464 Constance, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2025年

关键词：

Convergent synthesis; Malabaricane triterpenes; Mukaiyama aldol; Natural products; Total synthesis; ENANTIOSELECTIVE TOTAL-SYNTHESIS; DIHYDROXYLATION; OXIDATION; ETHERS;

D O I：

10.1002/anie.202506247

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the total synthesis of malabaricane triterpene sodagnitin E, marking the first synthesis of any malabaricane natural product to date. The enantioselective synthesis of two key fragments, followed by their coupling via a Mukaiyama aldol reaction delivered the triterpene framework in a convergent synthesis. A thorough analysis of the synthetic material led to the elucidation of a previously unassigned stereocenter (C17) as well as the reassignment of the configuration at C27. This enabled the structural revision of the relative configuration at the central lactol moiety.

引用

页数：5

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