Management of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

被引：0

作者：

Wine, Eytan ^{[1
,2
,3
]}

Aloi, Marina ^{[4
]}

Van Biervliet, Stephanie ^{[5
]}

Bronsky, Jiri ^{[6
]}

di Carpi, Javier Martin ^{[7
]}

Gasparetto, Marco ^{[8
]}

Gianolio, Laura ^{[9
]}

Gordon, Hannah ^{[10
]}

Hojsak, Iva ^{[11
]}

Hudson, Alexandra S. ^{[3
]}

Hussey, Seamus ^{[12
]}

van Limbergen, Johan ^{[13
]}

Miele, Erasmo ^{[14
]}

Norsa, Lorenzo ^{[8
]}

Olen, Ola ^{[15
]}

Pellino, Gianluca ^{[16
,17
]}

van Rheenen, Patrick ^{[18
]}

de Ridder, Lissy ^{[19
]}

Russell, Richard K. ^{[20
]}

Shouval, Dror S. ^{[21
,22
]}

Trindade, Eunice ^{[23
]}

Turner, Dan ^{[24
]}

Wilson, David C. ^{[25
]}

Yerushalmy Feler, Anat ^{[26
,27
]}

Assa, Amit ^{[24
]}

机构：

[1] Hosp Sick Children, Div Gastroenterol Hepatol & Nutr, Toronto, ON, Canada

[2] Univ Toronto, Toronto, ON, Canada

[3] Univ Alberta, Dept Pediat, Div Pediat Gastroenterol, Edmonton, AB, Canada

[4] Univ Milan, Osped Maggiore Policlin Milano, Fdn IRCCS Ca Granda, Dept Pathophysiol & Transplantat,Pediatr Gastroent, Milan, Italy

[5] Ghent Univ Hosp, Pediat Gastroenterol, Ghent, Belgium

[6] Univ Hosp Motol, Dept Paediat, Prague, Czech Republic

[7] Hosp St Joan Deu, Dept Pediat Gastroenterol Hepatol & Nutr, Barcelona, Spain

[8] Univ East Anglia UEA, Dept Paediat Gastroenterol, Norfolk & Norwich Univ Hosp, Jenny Lind Childrens Hosp,Fac Med & Hlth Sci, Norwich, England

[9] Univ Milan, Vittore Buzzi Childrens Hosp, Dept Paediat, Milan, Italy

[10] Oxford Univ Hosp NHS Trust, John Radcliffe Hosp, Translat Gastroenterol Unit, Oxford, England

[11] Univ Zagreb, Childrens Hosp Zagreb, Referral Ctr Pediat Gastroenterol & Nutr, Dept Pediat,Med Sch, Zagreb, Croatia

[12] Univ Coll Dublin, DOCHAS Grp, Childrens Hlth Ireland, Dublin, Ireland

[13] Amsterdam UMC, Emma Childrens Hosp, Div Paediat Gastroenterol & Nutr, Amsterdam, Netherlands

[14] Univ Naples Federico II, Dept Translat Med Sci, Sect Paediat, Naples, Italy

[15] Karolinska Inst, Dept Med Solna, Div Clin Epidemiol, Stockholm, Sweden

[16] Univ Autonoma Barcelona UAB, Vall Hebron Univ Hosp, Colorectal Surg, Barcelona, Spain

[17] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy

[18] Univ Groningen, Univ Med Ctr Groningen, Dept Paediat Gastroenterol Hepatol & Nutr, Groningen, Netherlands

[19] Erasmus MC Sophia Childrens Hosp, Dept Paediat Gastroenterol, Rotterdam, Netherlands

[20] Royal Hosp Children & Young People, Dept Paediat Gastroenterol, Edinburgh, Scotland

[21] Schneider Childrens Med Ctr Israel, Inst Gastroenterol Nutr & Liver Dis, Petah Tiqwa, Israel

[22] Tel Aviv Univ, Fac Med, Tel Aviv, Israel

[23] Ctr Hosp Univ Sao Joao, Pediat Gastroenterol & Nutr Unit, Porto, Portugal

[24] Hebrew Univ Jerusalem, Juliet Keidan Inst Paediat Gastroenterol & Nutr, Shaare Zedek Med Ctr, Eisenberg R&D Author, Jerusalem, Israel

[25] Univ Edinburgh, Ctr Inflammat Res, Child Life & Hlth, Edinburgh, Scotland

[26] Dana Dwek Childrens Hosp, Tel Aviv Sourasky Med Ctr, Pediat Gastroenterol Inst, Tel Aviv, Israel

[27] Tel Aviv Univ, Fac Med & Hlth Sci, Tel Aviv, Israel

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2025年

关键词：

biologics; children; inflammatory bowel disease-unclassified; Paediatric Ulcerative Colitis Activity Index; thiopurines; INFLAMMATORY-BOWEL-DISEASE; PRIMARY SCLEROSING CHOLANGITIS; IRON-DEFICIENCY ANEMIA; RANDOMIZED CONTROLLED-TRIAL; BONE-MINERAL DENSITY; IBD PORTO GROUP; METAANALYSIS COMPARATIVE EFFICACY; FECAL MICROBIOTA TRANSPLANT; QUALITY-OF-LIFE; 6-THIOGUANINE NUCLEOTIDE LEVELS;

D O I：

10.1002/jpn3.70097

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

ObjectivesDespite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points.MethodsThese guidelines are an update to those published in 2018 and are a joint effort of the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation. An extensive literature search with subsequent evidence appraisal using the Oxford methodology was performed, followed by three online voting sessions and a consensus face-to-face meeting. Thirty-nine recommendations and 77 practice points were endorsed by the 25 experts with at least an 84% consensus rate.ResultsRobust evidence-based recommendations and detailed practice points are provided. In addition to reemphasising and updating the role of more 'traditional' UC therapies, these guidelines outline optimising the use of antitumour necrosis factor therapies and integrating newer biologics and small molecules, as well as supportive therapy, to improve outcomes and provide an updated management algorithm. Measurement and monitoring tools and decision aids are provided, and additional aspects, including nutritional support, extraintestinal manifestations, pouchitis, inflammatory bowel disease-unclassified and patient support, are discussed. Some aspects, including surgery and thromboprophylaxis, are covered in the acute severe UC guidelines.ConclusionsThese guidelines serve as an aid in managing children with UC through a combination of evidence-based recommendations and more practical practice points in the ambulatory setting.

引用

页数：51

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