The Application of N-Aryl Glycines and Their Analogues in Visible-Light-Promoted Photoredox Catalysis

被引：0

作者：

Wei, Jian ^{[1
]}

Yang, Hongjian ^{[3
]}

He, Qidi ^{[1
]}

Wang, Taimin ^{[2
]}

Cheng, Bin ^{[2
]}

机构：

[1] Guangzhou Qual Supervis & Testing Inst, Innovat Ctr NQI Qual Safety Guangzhou, Guangzhou 510000, Peoples R China

[2] Shenzhen Polytech Univ, Sch Food & Drug, Dept Undergrad Educ, Shenzhen 518055, Peoples R China

[3] Foshan Ionova Biotherapeut Co Inc, Guangzhou 528000, Guangdong, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2025年

关键词：

Aminomethylation; N-aryl glycine; N-heterocycle; Photoredox catalysis; Radical coupling; PRIVILEGED SCAFFOLD; COMBINING ENZYME; TRANSITION-METAL; AMINO RADICALS; DERIVATIVES; FUNCTIONALIZATION; PHOTOCATALYSIS; ACIDS; TRANSFORMATIONS; ISOXAZOLIDINE;

D O I：

10.1002/asia.202500153

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aminomethylation reaction, a fundamental and versatile organic transformation is extensively utilized to incorporate an aminomethyl group into target molecules and plays a significant role in the synthesis of natural products and functional molecules. In recent years, N-Aryl glycines and their analogues have been widely explored in visible-light-promoted photoredox reactions to install an aminomethyl moiety or construct various N-heterocycles under mild conditions. Their key reaction intermediates are alpha-aminoalkyl radicals, imines, or iminium ions. Recent advances in this field have been summarized into five categories according to the proposed reaction mechanisms: (i) radical addition initiated aminomethylation reactions, (ii) radical-radical cross coupling reactions, (iii) radical-triggered annulation reactions, (iv) transformations involving imines, and (v) metallophotoredox dual catalysis. We hope this review will give an overview of visible-light-promoted photoredox reactions of N-aryl glycines and their analogues and drive further research progress in this area.

引用

页数：22

共 146 条

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