A Literature Review of Real-World Effectiveness and Safety of Dupilumab for Atopic Dermatitis

被引：60

作者：

Kamata, Masahiro ^{[1
]}

Tada, Yayoi ^{[1
]}

机构：

[1] Teikyo Univ, Sch Med, Dept Dermatol, 2-11-1 Kaga,Itabashi Ku, Tokyo 1738605, Japan

来源：

JID INNOVATIONS | 2021年 / 1卷 / 03期

关键词：

TOPICAL CORTICOSTEROIDS; LABORATORY SAFETY; PERSISTENT ASTHMA; DOUBLE-BLIND; ADULTS; MODERATE; PLACEBO; EFFICACY; RISK; IMMUNOGENICITY;

D O I：

10.1016/j.xjidi.2021.100042

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) is a chronic inflammatory skin disease with pruritus, characterized by recurrent eczema with exacerbations and remissions. AD impairs patients' QOL and places a heavy burden on patients. Recently, dupilumab, an anti-IL-4Ra antibody, was approved for the treatment of patients with moderate-to-severe AD who are refractory to topical agents and/ or conventional systemic therapy. Clinical trials of dupilumab for AD demonstrated high efficacy and tolerable safety profiles. Furthermore, real-world evidence of dupilumab for AD is accumulating. Most of these data show favorable effectiveness and safety profile; however, they also clarified issues, including conjunctivitis and facial redness. There are still a certain number of patients with significant failure. In this article, we review real-world evidence of dupilumab for AD, identify concerns specific to dupilumab, and discuss unmet needs and issues to be addressed in the future.

引用

页数：12

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