Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

被引：0

作者：

Gemander, Nicolas ^{[1
,2
,3
]}

Neumann, Julika ^{[4
,5
]}

Veiga, Rafael ^{[6
,7
]}

Etienne, Isabelle ^{[1
,2
,8
]}

Prezzemolo, Teresa ^{[4
]}

Kemlin, Delphine ^{[1
,2
,3
]}

Pannus, Pieter ^{[1
,2
]}

Depickere, Stephanie ^{[9
]}

Olislagers, Veronique ^{[1
,2
]}

Duc, Ines Vu ^{[1
,2
]}

Waegemans, Alexandra ^{[1
,2
]}

Gerbaux, Margaux ^{[4
]}

Bucken, Leoni ^{[4
]}

Dahma, Hafid ^{[10
]}

Martin, Charlotte ^{[11
]}

Dauby, Nicolas ^{[11
]}

Goossens, Maria E. ^{[9
]}

Desombere, Isabelle ^{[9
]}

Roca, Carlos P. ^{[6
]}

Willemsen, Mathijs ^{[4
,5
]}

Goriely, Stanislas ^{[1
,2
]}

Le Moine, Alain ^{[1
,2
,3
]}

Marchant, Arnaud ^{[1
,2
]}

Liston, Adrian ^{[6
,7
]}

Humblet-Baron, Stephanie ^{[4
]}

机构：

[1] Univ Libre Bruxelles ULB, European Plotkin Inst Vaccinol, Brussels, Belgium

[2] Univ Libre Bruxelles ULB, ULB Ctr Res Immunol U CRI, Gosselies, Belgium

[3] Univ Libre Bruxelles ULB, HUB Erasme, Dept Nephrol Dialysis & Renal Transplantat, Brussels, Belgium

[4] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Leuven, Belgium

[5] VIB Ctr Brain & Dis Res, Leuven, Belgium

[6] Babraham Inst, Immunol Programme, Cambridge, England

[7] Univ Cambridge, Dept Pathol, Cambridge, England

[8] Univ Libre Bruxelles ULB, Chest Dept, HUB Erasme, Brussels, Belgium

[9] Sciensano, Dept Infect Dis Humans, Brussels, Belgium

[10] LHUB ULB Lab Hosp Univ Bruxelles, Microbiol, Brussels, Belgium

[11] Univ Libre Bruxelles ULB, CHU St Pierre, Dept Infect Dis, Brussels, Belgium

来源：

NPJ VACCINES | 2025年 / 10卷 / 01期

基金：

欧盟地平线“2020”; 英国生物技术与生命科学研究理事会;

关键词：

KIDNEY-TRANSPLANT; MYCOPHENOLATE-MOFETIL; DIALYSIS PATIENTS; INFLUENZA; COVID-19; SURVIVAL; ANTIBODY; HEMODIALYSIS; SIGNATURE; MORTALITY;

D O I：

10.1038/s41541-025-01182-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Solid-organ transplant (SOT) recipients are at enhanced risk of infection and to poorly respond to vaccination due to comorbidities and immunosuppression. We performed a systems vaccinology study in 59 kidney and 31 lung transplant recipients who received 3 doses of COVID-19 mRNA BNT162b2 vaccine. We were able to characterize a baseline configuration associated with an effective humoral response to 3 doses, characterized by an innate and activated B cell profile, whereas a T cell signature was associated with a poorer response. We observed a distinct configuration associated with a detectable humoral response to 2 doses, partly mediated by double negative B cell subsets. These results suggest that, despite their immunosuppression, some SOT recipients can induce an effective humoral response to 3 doses of vaccine supported by a baseline configuration close to the healthy phenotype. Baseline immune phenotyping may help identify SOT recipients at the greatest risk of a poor vaccine response.

引用

页数：15

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