Evolving Characteristics of Type 2 Diabetes Mellitus in East Asia

被引：0
作者：
Lee, Joonyub [1 ]
Yoon, Kun-Ho [1 ]
机构：
[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Endocrinol & Metab, 222 Banpo Daero, Seoul 06591, South Korea
来源：
ENDOCRINOLOGY AND METABOLISM | 2025年 / 40卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Diabetes mellitus; type; 2; Insulin secretion; Insulin resistance; Asia; eastern; Prevalence; Incidence; BETA-CELL MASS; INSULIN SENSITIVITY; GLUCOSE-TOLERANCE; SECRETION; OBESITY; RISK; EPIDEMIOLOGY; PATHOGENESIS; POPULATION; PREVALENCE;
D O I：
10.3803/EnM.2024.2193
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In East Asians, type 2 diabetes mellitus (T2DM) is primarily characterized by significant defects in insulin secretion and comparatively low insulin resistance. Recently, the prevalence of T2DM has rapidly increased in East Asian countries, including Korea, occurring concurrently with rising obesity rates. This trend has led to an increase in the average body mass index among East Asian T2DM patients, highlighting the influence of insulin resistance in the development of T2DM within this group. Currently, the incidence of T2DM in Korea is declining, which may indicate potential adaptive changes in insulin secretory capacity. This review focuses on the changing epidemiology of T2DM in East Asia, with a particular emphasis on the characteristics of peak functional f-cell mass.
引用
收藏
页码：57 / 63
页数：7
相关论文
共 65 条
[1]  
[Anonymous], 1981, Zhonghua Nei Ke Za Zhi, V20, P678
[2]   Diabetes Fact Sheet in Korea 2021 [J].
Bae, Jae Hyun ;
Han, Kyung-Do ;
Ko, Seung-Hyun ;
Yang, Ye Seul ;
Choi, Jong Han ;
Choi, Kyung Mook ;
Kwon, Hyuk-Sang ;
Won, Kyu Chang .
DIABETES & METABOLISM JOURNAL, 2022, 46 (03) :417-426
[3]   The fetal origins of type 2 diabetes mellitus [J].
Barker, DJP .
ANNALS OF INTERNAL MEDICINE, 1999, 130 (04) :322-324
[4]   Diabetes in Asia Epidemiology, Risk Factors, and Pathophysiology [J].
Chan, Juliana C. N. ;
Malik, Vasanti ;
Jia, Weiping ;
Kadowaki, Takashi ;
Yajnik, Chittaranjan S. ;
Yoon, Kun-Ho ;
Hu, Frank B. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (20) :2129-2140
[5]   Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk [J].
Chiou, Joshua ;
Zeng, Chun ;
Cheng, Zhang ;
Han, Jee Yun ;
Schlichting, Michael ;
Miller, Michael ;
Mendez, Robert ;
Huang, Serina ;
Wang, Jinzhao ;
Sui, Yinghui ;
Deogaygay, Allison ;
Okino, Mei-Lin ;
Qiu, Yunjiang ;
Sun, Ying ;
Kudtarkar, Parul ;
Fang, Rongxin ;
Preissl, Sebastian ;
Sander, Maike ;
Gorkin, David U. ;
Gaulton, Kyle J. .
NATURE GENETICS, 2021, 53 (04) :455-+
[6]   β-cell mass in people with type 2 diabetes [J].
Cho, Jae-Hyoung ;
Kim, Ji-Won ;
Shin, Jeong-Ah ;
Shin, Juyoung ;
Yoon, Kun-Ho .
JOURNAL OF DIABETES INVESTIGATION, 2011, 2 (01) :6-17
[7]   Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians [J].
Cho, Yoon Shin ;
Chen, Chien-Hsiun ;
Hu, Cheng ;
Long, Jirong ;
Ong, Rick Twee Hee ;
Sim, Xueling ;
Takeuchi, Fumihiko ;
Wu, Ying ;
Go, Min Jin ;
Yamauchi, Toshimasa ;
Chang, Yi-Cheng ;
Kwak, Soo Heon ;
Ma, Ronald C. W. ;
Yamamoto, Ken ;
Adair, Linda S. ;
Aung, Tin ;
Cai, Qiuyin ;
Chang, Li-Ching ;
Chen, Yuan-Tsong ;
Gao, Yutang ;
Hu, Frank B. ;
Kim, Hyung-Lae ;
Kim, Sangsoo ;
Kim, Young Jin ;
Lee, Jeannette Jen-Mai ;
Lee, Nanette R. ;
Li, Yun ;
Liu, Jian Jun ;
Lu, Wei ;
Nakamura, Jiro ;
Nakashima, Eitaro ;
Ng, Daniel Peng-Keat ;
Tay, Wan Ting ;
Tsai, Fuu-Jen ;
Wong, Tien Yin ;
Yokota, Mitsuhiro ;
Zheng, Wei ;
Zhang, Rong ;
Wang, Congrong ;
So, Wing Yee ;
Ohnaka, Keizo ;
Ikegami, Hiroshi ;
Hara, Kazuo ;
Cho, Young Min ;
Cho, Nam H. ;
Chang, Tien-Jyun ;
Bao, Yuqian ;
Hedman, Asa K. ;
Morris, Andrew P. ;
McCarthy, Mark I. .
NATURE GENETICS, 2012, 44 (01) :67-U97
[8]  
Choi Yoon Hee, 2000, Korean Journal of Internal Medicine, V15, P211
[9]   Pathogenesis of type 2 diabetes mellitus [J].
DeFronzo, RA .
MEDICAL CLINICS OF NORTH AMERICA, 2004, 88 (04) :787-+
[10]   Maternal Protein Restriction Leads to Pancreatic Failure in Offspring: Role of Misexpressed MicroRNA-375 [J].
Dumortier, Olivier ;
Hinault, Charlotte ;
Gautier, Nadine ;
Patouraux, Stephanie ;
Casamento, Virginie ;
Van Obberghen, Emmanuel .
DIABETES, 2014, 63 (10) :3416-3427
1234567