Duke activity status index is not predictive of outcomes after kidney transplantation: a retrospective observational study

被引：0

作者：

Fergie, Ruth ^{[1
,2
]}

Maxwell, Alexander P. ^{[1
]}

Courtney, Aisling E. ^{[2
]}

Corr, Michael ^{[1
,2
]}

O'Neill, Stephen ^{[2
]}

Cunningham, Emma L. ^{[1
]}

机构：

[1] Queens Univ Belfast, Ctr Publ Hlth, Belfast, North Ireland

[2] Belfast City Hosp, Reg Nephrol & Transplant Unit, Belfast BT9 7AB, Antrim, North Ireland

来源：

BMC NEPHROLOGY | 2025年 / 26卷 / 01期

关键词：

Kidney transplant; End-stage kidney disease; Functional capacity; EARLY HOSPITAL READMISSION; LENGTH-OF-STAY; FUNCTIONAL-CAPACITY; GRAFT LOSS; FRAILTY; MORTALITY; RISK; RECIPIENTS; SURVIVAL; SURGERY;

D O I：

10.1186/s12882-025-04300-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundReduced functional capacity increases the risk of adverse outcomes after kidney transplantation. The Duke Activity Status Index is a measurement of physical function, previously reported as being predictive of adverse outcomes after major non-cardiac surgery. This study assessed the ability of the Duke Activity Status Index to predict adverse outcomes for patients undergoing kidney transplantation.MethodsAdult kidney transplant recipients with a Duke Activity Status Index calculated at time of listing for transplantation in Northern Ireland between 2019 and 2024 were analysed. Dichotomous outcomes (delayed graft function, unplanned critical care admission, 30-day hospital re-admission, 30-day severe postoperative complication, 30-day cardiovascular complication) were analysed using multivariate logistic regression. Post-transplant length of stay was assessed using multivariate linear regression. All-cause mortality and death-censored graft loss were evaluated using Cox proportional hazard regression models.ResultsData was available for 408 kidney transplant recipients. Duke Activity Status Index was not predictive of delayed graft function (aOR 0.99 (95% CI 0.66-1.01) p = 0.359), unplanned critical care admission (aOR1.00 (95% CI 0.97-1.04), p = 0.866), length-of-stay post-transplant, 30-day hospital re-admission (aOR1.01 (95% CI 0.99-1.03), p = 0.457), 30-day severe postoperative complication (aOR 1.01 (95% CI 0.99-1.03) p = 0.489), 30-day cardiovascular complication (aOR 0.99 (95% CI 0.93-1.06), p = 0.850), all-cause mortality (aHR 1.00 (0.96-1.04), p = 0.89) or death-censored graft loss (aHR 0.97 (95% CI 0.93-1.01), p = 0.14).ConclusionsIn this cohort, the Duke Activity Status Index was not an independent predictor of short or long-term adverse outcomes following kidney transplantation. These findings suggest that the Duke Activity Status Index may have limited utility in assessing functional capacity in waitlisted kidney transplant candidates.Trial registrationNot applicable.

引用

页数：9

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