The cognitive and neurological implications of toxoplasma gondii infection: Evidence from a systematic review and meta-analysis

被引：0

作者：

Kavakebian, Mahshid ^{[1
,2
]}

Ghandali, Tina ^{[1
,2
]}

Nasiri, Hasti ^{[1
,2
]}

Ramezani-Moghadam, Fatemeh ^{[1
,2
]}

Alizadeh, Saba ^{[1
,2
]}

Alizadeh, Sara ^{[1
,2
]}

Silakhor, Melika ^{[1
,2
]}

Rajabi, Mohamad ^{[1
,2
]}

Mirmazhari, Amirali ^{[3
,4
]}

Asgarian, Parham ^{[1
,2
]}

Rahimi, Hosein ^{[2
,5
]}

Karimi, Mehdi ^{[1
,2
]}

Moosazadeh, Mahmood ^{[6
]}

机构：

[1] Mazandaran Univ Med Sci, Bu Ali Sina Hosp, Neurol Res Ctr, Sch Med, 20 Pasdaran Blvd, Sari 4815838477, Mazandaran, Iran

[2] Mazandaran Univ Med Sci, Fac Med, Student Res Comm, Immunol Res Comm, Km 18,Khazarabad Rd,Payambar Azam Univ Complex, Sari, Mazandaran, Iran

[3] Mazandaran Univ Med Sci, Sch Adv Med Technol, Dept Med Biotechnol, Km 18,Khazarabad Rd,Payambar Azam Univ Complex, Sari, Mazandaran, Iran

[4] Mazandaran Univ Med Sci, Student Res Comm, Fac Allied Med Sci, 20 Maallem Sq,Res & Technol Deputy Bldg,3rd Floor, Sari 4815733971, Mazandaran, Iran

[5] Mazandaran Univ Med Sci, Dept Immunol, Immunol Res Comm, Fac Med, Km 18,Khazarabad Rd,Payambar Azam Univ Complex, Sari, Mazandaran, Iran

[6] Mazandaran Univ Med Sci, Student Res Comm Off, Noncommunicable Dis Inst, Gastrointestinal Canc Res Ctr, 20 Maallem Sq,Res & Technol Deputy Bldg,3rd Floor, Sari 4815733971, Mazandaran, Iran

来源：

ACTA TROPICA | 2025年 / 268卷

关键词：

Alzheimer's disease; Cognitive domains; Cognitive impairment; Meta-analysis; Neurodegeneration; Parkinson's disease; Toxoplasma gondii; SEROPOSITIVITY; ASSOCIATION; MEMORY;

D O I：

10.1016/j.actatropica.2025.107705

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Toxoplasma gondii, a neurotropic parasite, has been implicated in cognitive decline and neurodegenerative disorders, particularly Alzheimer's disease (AD) and, to a lesser extent, Parkinson's disease (PD). While frequently asymptomatic, latent infections can disrupt neurotransmitter systems, provoke chronic neuroinflammation, and impair neuronal metabolism-mechanisms that may accelerate cognitive deterioration. This systematic review and meta-analysis included 34 observational studies with over 24,000 participants, evaluating the association between T. gondii infection and cognitive outcomes in both AD and PD populations. Meta-analytical findings demonstrated a significant association between T. gondii infection and AD (log OR: 0.52; 95 % CI: 0.25-0.79), with pronounced impairments observed in global cognition, verbal fluency, and memory domains. In contrast, no statistically significant association was found between T. gondii infection and PD. These findings support a potential role for T. gondii in AD pathogenesis through mechanisms such as neuroinflammation and synaptic dysfunction, while its relevance to PD remains inconclusive. Longitudinal and mechanistic studies are warranted to further clarify causality and inform potential therapeutic strategies targeting parasite-mediated neural injury.

引用

页数：13

共 76 条

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