Exosomes and Their miRNA as a Potential Biomarker in the Diagnosis of Parkinson's Disease

被引：0

作者：

Vijayakumar, Srilakshmi ^{[1
]}

Yesudhason, Beryl Vedha ^{[1
]}

Anandharaj, Jenif Leo ^{[1
]}

Kalaivanan, Logaratshai ^{[1
]}

Christyraj, Johnson Retnaraj Samuel Selvan ^{[1
]}

机构：

[1] Sathyabama Inst Sci & Technol, Ctr Mol & Nanomed Sci, Int Res Ctr, Regenerat & Stem Cell Biol Lab, Chennai 600119, Tamil Nadu, India

来源：

ACS CHEMICAL NEUROSCIENCE | 2025年 / 16卷 / 15期

关键词：

exosomes; biomarker; extracellular vesicles; Parkinson'sdisease; miRNA; diagnosis; EXTRACELLULAR VESICLES; MOLECULAR COMPOSITIONS; MICRORNA BIOGENESIS; ALZHEIMERS-DISEASE; DELIVERY; CELL; MECHANISM; RNAS; IDENTIFICATION; PATHOGENESIS;

D O I：

10.1021/acschemneuro.5c00313

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes are the smallest of the extracellular vesicles, essential in intercellular communication by transporting lipids, proteins, and RNA, thereby influencing the recipient cells. The exosomes from cerebrospinal fluid, central nervous system, and other body fluids have substantial modifications in their molecular composition under various disease conditions. Recent research suggests their potential use as biomarkers for early and prompt detection of neurodegenerative disorders, particularly Parkinson's disease (PD), which is characterized by the misfolded aggregates of the alpha-synuclein protein. Notably, exosome-based dysregulated microRNAs (miRNAs) are emerging as potential biomarkers for accurate Parkinson's disease diagnosis. Exosomal miRNAs' potential and limitations as early diagnostic biomarkers for Parkinson's disease are discussed comprehensively in this review.

引用

页码：2756 / 2766

页数：11

共 95 条

[1] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[2] Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Schapira, Anthony H. ;

Gardiner, Chris ;

Sargent, Ian L. ;

Wood, Matthew J. A. ;

Cooper, J. Mark .

NEUROBIOLOGY OF DISEASE, 2011, 42 (03) :360-367

[3] Biogenesis and function of extracellular vesicles in cancer [J].

Bebelman, Maarten P. ;

Smit, Martine J. ;

Pegtel, D. Michiel ;

Baglio, S. Rubina .

PHARMACOLOGY & THERAPEUTICS, 2018, 188 :1-11

[4] Alzheimer's disease [J].

Scheltens, Philip ;

De Strooper, Bart ;

Kivipelto, Miia ;

Holstege, Henne ;

Chetelat, Gael ;

Teunissen, Charlotte E. ;

Cummings, Jeffrey ;

van der Flier, Wiesje M. .

LANCET, 2021, 397 (10284) :1577-1590

[5] Identification of Blood Serum Micro-RNAs Associated With Idiopathic and LRRK2 Parkinson's Disease [J].

Botta-Orfila, Teresa ;

Morato, Xavier ;

Compta, Yaroslau ;

Jose Lozano, Juan ;

Falgas, Neus ;

Valldeoriola, Francesc ;

Pont-Sunyer, Claustre ;

Vilas, Dolores ;

Mengual, Lourdes ;

Fernandez, Manel ;

Luis Molinuevo, Jose ;

Antonell, Anna ;

Jose Marti, Maria ;

Fernandez-Santiago, Ruben ;

Ezquerra, Mario .

JOURNAL OF NEUROSCIENCE RESEARCH, 2014, 92 (08) :1071-1077

[6] Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD [J].

Chang, Chongwang ;

Lang, Hongjuan ;

Geng, Ning ;

Wang, Jing ;

Li, Nan ;

Wang, Xuelian .

NEUROSCIENCE LETTERS, 2013, 548 :190-195

[7]

Chen CF, 2011, METHODS MOL BIOL, V687, P113, DOI 10.1007/978-1-60761-944-4_8

[8] Real-time quantification of microRNAs by stem-loop RT-PCR [J].

Chen, CF ;

Ridzon, DA ;

Broomer, AJ ;

Zhou, ZH ;

Lee, DH ;

Nguyen, JT ;

Barbisin, M ;

Xu, NL ;

Mahuvakar, VR ;

Andersen, MR ;

Lao, KQ ;

Livak, KJ ;

Guegler, KJ .

NUCLEIC ACIDS RESEARCH, 2005, 33 (20) :e179.1-e179.9

[9] MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease [J].

Chen, Yimeng ;

Gao, Chao ;

Sun, Qian ;

Pan, Hong ;

Huang, Pei ;

Ding, Jianqing ;

Chen, Shengdi .

FRONTIERS IN AGING NEUROSCIENCE, 2017, 9

[10] Recent advances in signal amplification strategy based on oligonucleotide and nanomaterials for microRNA detection-a review [J].

Chen, Ying-Xu ;

Huang, Ke-Jing ;

Niu, Ke-Xin .

BIOSENSORS & BIOELECTRONICS, 2018, 99 :612-624

← 1 2 3 4 5 6 7 8 9 10 →