Subtyping depression in the rheumatic diseases by cluster analysis

被引：0

作者：

Zhao, Yaqi ^{[1
]}

Yan, Suyan ^{[2
]}

Li, Xinya ^{[2
]}

Xu, Wei ^{[1
,2
]}

Liu, Baocheng ^{[2
]}

Ma, Zhenzhen ^{[1
,2
]}

Yang, Qingrui ^{[1
,2
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Rheumatol & Immunol, Jinan, Shandong, Peoples R China

[2] Shandong First Med Univ, Shandong Prov Hosp, Dept Rheumatol & Immunol, Jinan, Shandong, Peoples R China

来源：

CLINICAL RHEUMATOLOGY | 2025年

基金：

中国国家自然科学基金;

关键词：

Major depressive disorder; Rheumatoid arthritis; Rheumatological diseases; Spondyloarthritis; Systemic lupus erythematosus; SOCIETY CLASSIFICATION CRITERIA; AMERICAN-COLLEGE; RISK; INFLAMMATION; VALIDATION; ARTHRITIS; SYMPTOMS; PAPER;

D O I：

10.1007/s10067-025-07586-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveMajor depressive disorder (MDD) and rheumatic diseases (RD) interact to exacerbate disease outcomes. The purpose of this study was to assess the prevalence and associated factors of depression in RD patients in order to identify independent predictors of mental health disorders risk and apply cluster analysis to identify homogeneous groups in a population of approximately 47 patients with RD-MDD to achieve precise treatment and early prevention of complications.MethodsIn total, 205 RD patients were included in this study. We used the Profile of Mood State (POMS) and Patient Health Questionnaire-9 (PHQ-9) to assess the patients' state of mind. A cluster analysis was applied according to six clinical and serological variables to define different subgroups of patients.ResultsThe rate of depression in RD patients in our study was 22.9%. Sex (female), disease duration, and disease activity are risk factors for the development of depression. Albumin is a protective factor for MDD. RD-MDD patients were clustered in two groups. Cluster 1 (n = 30, 63.8%): patients were of older age, lower education and income levels, low disease activity, and mild depressive symptoms. Cluster 2 (n = 17, 36.2%): Young women with higher education and income levels, high disease activity, and more severe depressive symptoms.ConclusionOur findings provide evidence indicating that RD-MDD presents varying clinical phenotypes and the treatment varies accordingly, suggesting the need for individualized treatment. Key Points center dot Depression is often comorbid in patients with rheumatic diseases. The two interact and aggravate the patient's condition.center dot The rate of depression in RD patients in our study was 22.9%. Sex (female), disease duration, and disease activity are risk factors for the development of depression. Albumin is a protective factor for MDD.center dot RD-MDD patients were clustered in two groups through cluster analysis in order to guide individualized treatment.

引用

页数：9

共 32 条

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