The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress

被引：0

作者：

Zhang, Haokun ^{[1
,2
,3
]}

Hang, Wang ^{[1
,2
,3
]}

Jing, Zhaohui ^{[1
,2
,3
]}

Liu, Bingyan ^{[1
,2
,3
]}

Wang, Xiaoxiao ^{[1
,2
,3
]}

Li, Yilin ^{[1
,2
,3
]}

Luo, Huomin ^{[1
,2
,3
]}

Lv, Huilin ^{[1
,2
,3
]}

Tao, Xingyue ^{[1
,2
,3
]}

Timashev, Peter ^{[4
]}

Li, Yuzhen ^{[5
]}

Li, Peifeng ^{[1
,2
,3
]}

机构：

[1] Zhengzhou Univ Light Ind, Coll Food & Bioengn, Zhengzhou, Peoples R China

[2] Zhengzhou Univ Light Ind, Henan Key Lab Cold Chain Food Qual & Safety Contro, Zhengzhou, Peoples R China

[3] Zhengzhou Univ Light Ind, Inst Life & Hlth, Zhengzhou, Peoples R China

[4] Sechenov Univ, Inst Regenerat Med Sechenov First Moscow State Med, Moscow, Russia

[5] Chinese Peoples Liberat Army Gen Hosp, Grad Sch, Basic Med Dept, Beijing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷

关键词：

notch signaling pathway; cancer; tumor development; therapeutic potential; clinical progress; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN HEPATOCELLULAR-CARCINOMA; SQUAMOUS-CELL CARCINOMA; GASTRIC-CANCER; CYCLE ARREST; EXPRESSION; APOPTOSIS; STEM; ACTIVATION; INHIBITION;

D O I：

10.3389/fimmu.2025.1567524

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article presents a comprehensive literature review on the role of the Notch signaling pathway in cancer and its molecular mechanisms. The Notch signaling pathway plays an important role in various types of cancer by regulating key biological processes such as epithelial-endothelial transition, angiogenesis, apoptosis and metabolic reprogramming. This article reviews the relevant mechanisms of the Notch signaling pathway in colorectal cancer, ovarian cancer, oral squamous cell carcinoma, gastric cancer and chronic lymphocytic leukemia, highlighting its dual roles in promoting tumor growth, inhibiting tumor progression and potential therapeutic applications in oncology. Meanwhile, the key roles of the Notch signaling pathway in regulating tumor drug resistance and shaping the tumor microenvironment are discussed, highlighting its importance in clinical applications. Through this review, some ideas and hints for future research directions can be provided to the readers of Notch pathway related research.

引用

页数：12

共 107 条

[1] The Roles of Notch Signaling in Liver Development and Disease [J].

Adams, Joshua M. ;

Jafar-Nejad, Hamed .

BIOMOLECULES, 2019, 9 (10)

[2] The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms [J].

Alaggio, Rita ;

Amador, Catalina ;

Anagnostopoulos, Ioannis ;

Attygalle, Ayoma D. ;

Araujo, Iguaracyra Barreto de Oliveira ;

Berti, Emilio ;

Bhagat, Govind ;

Borges, Anita Maria ;

Boyer, Daniel ;

Calaminici, Mariarita ;

Chadburn, Amy ;

Chan, John K. C. ;

Cheuk, Wah ;

Chng, Wee-Joo ;

Choi, John K. ;

Chuang, Shih-Sung ;

Coupland, Sarah E. ;

Czader, Magdalena ;

Dave, Sandeep S. ;

de Jong, Daphne ;

Du, Ming-Qing ;

Elenitoba-Johnson, Kojo S. ;

Ferry, Judith ;

Geyer, Julia ;

Gratzinger, Dita ;

Guitart, Joan ;

Gujral, Sumeet ;

Harris, Marian ;

Harrison, Christine J. ;

Hartmann, Sylvia ;

Hochhaus, Andreas ;

Jansen, Patty M. ;

Karube, Kennosuke ;

Kempf, Werner ;

Khoury, Joseph ;

Kimura, Hiroshi ;

Klapper, Wolfram ;

Kovach, Alexandra E. ;

Kumar, Shaji ;

Lazar, Alexander J. ;

Lazzi, Stefano ;

Leoncini, Lorenzo ;

Leung, Nelson ;

Leventaki, Vasiliki ;

Li, Xiao-Qiu ;

Lim, Megan S. ;

Liu, Wei-Ping ;

Louissaint, Abner, Jr. ;

Marcogliese, Andrea ;

Medeiros, L. Jeffrey .

LEUKEMIA, 2022, 36 (07) :1720-1748

[3] Druggable Molecular Pathways in Chronic Lymphocytic Leukemia [J].

Almasri, Mohammad ;

Amer, Marah ;

Ghanej, Joseph ;

Mahmoud, Abdurraouf Mokhtar ;

Gaidano, Gianluca ;

Moia, Riccardo .

LIFE-BASEL, 2022, 12 (02)

[4] Increased Notch1 Expression Is Associated With Poor Overall Survival in Patients With Ovarian Cancer [J].

Alniaimi, Ahmed Numan ;

Demorest-Hayes, Kristin ;

Alexander, Vinita M. ;

Seo, Songwon ;

Yang, David ;

Rose, Stephen .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2015, 25 (02) :208-213

[5] A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer [J].

Arcaroli, John J. ;

Tai, W. M. ;

McWilliams, Ryan ;

Bagby, Stacey ;

Blatchford, Patrick J. ;

Varella-Garcia, Marileila ;

Purkey, Alicia ;

Quackenbush, Kevin S. ;

Song, Eun-Kee ;

Pitts, Todd M. ;

Gao, Dexiang ;

Lieu, Chris ;

McManus, Martine ;

Tan, Aik Choon ;

Zheng, Xianxian ;

Zhang, Qin ;

Ozeck, Mark ;

Olson, Peter ;

Jiang, Zhi-Qin ;

Kopetz, Scott ;

Jimeno, Antonio ;

Keysar, Stephen ;

Eckhardt, Gail ;

Messersmith, Wells A. .

INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (01) :195-205

[6] Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia [J].

Baldoni, Stefano ;

Del Papa, Beatrice ;

Dorillo, Erica ;

Aureli, Patrizia ;

De Falco, Filomena ;

Rompietti, Chiara ;

Sorcini, Daniele ;

Varasano, Emanuela ;

Cecchini, Debora ;

Zei, Tiziana ;

Di Tommaso, Ambra ;

Rosati, Emanuela ;

Alexe, Gabriela ;

Roti, Giovanni ;

Stegmaier, Kimberly ;

Di Ianni, Mauro ;

Falzetti, Franca ;

Sportoletti, Paolo .

INTERNATIONAL JOURNAL OF CANCER, 2018, 143 (04) :958-970

[7] Role of Notch Signaling Pathway in Glioblastoma Pathogenesis [J].

Bazzoni, Riccardo ;

Bentivegna, Angela .

CANCERS, 2019, 11 (03)

[8] Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression [J].

Beverly, LJ ;

Felsher, DW ;

Capobianco, AJ .

CANCER RESEARCH, 2005, 65 (16) :7159-7168

[9]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[10] Notch pathway inhibition targets chemoresistant insulinoma cancer stem cells [J].

Capodanno, Y. ;

Buishand, F. O. ;

Pang, L. Y. ;

Kirpensteijn, J. ;

Mol, J. A. ;

Argyle, D. J. .

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