Complete Remission of Acute-onset Autoimmune Hepatitis Following Transcatheter Splenic Arterial Embolization and Splenectomy for Spontaneous Splenic Rupture

被引：0

作者：

Sekai, Ikue

Takita, Masahiro

Yasuhara, Shigenobu

Omaru, Naoya

Matsubara, Takuya

Morita, Masahiro

Chishina, Hirokazu

Minaga, Kosuke

Hagiwara, Satoru

Ida, Hiroshi

Kojima, Misa

Maenishi, Osamu

Watanabe, Tomohiro ^{[1
]}

Kudo, Masatoshi

机构：

[1] Kindai Univ, Fac Med, Dept Gastroenterol & Hepatol, Higashiosaka, Japan

来源：

INTERNAL MEDICINE | 2025年

基金：

日本学术振兴会;

关键词：

Autoimmune hepatitis; Spleen; Splenectomy; Spontaneous splenic rupture; URSODEOXYCHOLIC ACID; JAPANESE PATIENTS; LIVER; FEATURES; MODELS; CELLS;

D O I：

10.2169/internalmedicine.5735-25

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 62-year-old woman presented with jaundice and fatigue. A blood examination revealed markedly elevated serum transaminase and bilirubin levels and negative hepatitis virus markers. A radiographic examination revealed no bile duct abnormalities. Serum transaminase levels decreased and normalized without immunosuppression after transcatheter arterial embolization and splenectomy for spontaneous splenic rupture, respectively. The pathological findings of the liver biopsy specimens were consistent with those of acuteonset autoimmune hepatitis (AIH), despite normal serum IgG levels. The clinical course of the present case suggests that pathogenic immune responses associated with acute-onset AIH may arise in the spleen, but not in the liver.

引用

页数：6

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