Therapeutic potential of P2X7 receptor in retinal diseases

被引：0
作者：
Wen, Min [1 ]
Xu, Qin [3 ]
Xie, Jinfeng [2 ]
Wu, Rong [2 ]
Chen, Xiaomei [1 ]
Wen, Nianlian [3 ]
Huang, Sheng [3 ]
机构：
[1] Zunyi Med Univ, Zunyi 563000, Guizhou, Peoples R China
[2] Jishou Univ, Med Coll, Jishou 416000, Hunan, Peoples R China
[3] Tongren Municipal Peoples Hosp, Dept Ophthalmol, Tongren 554300, Guizhou, Peoples R China
来源：
PURINERGIC SIGNALLING | 2025年
关键词：
Diabetic retinopathy; Age-related macular degeneration; Glaucoma; P2X(7)-INDUCED PORE FORMATION; GANGLION-CELL DEATH; MACULAR DEGENERATION; DIABETIC-RETINOPATHY; NUCLEOTIDE RECEPTOR; OXIDATIVE STRESS; ACTIVATION; MICROGLIA; ATP; INFLAMMATION;
D O I：
10.1007/s11302-025-10104-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Retinal diseases affect the health of millions of people worldwide and activated P2X7 receptors (P2X7Rs) are associated with the pathophysiology of a variety of retina-related diseases, including diabetic retinopathy, age-related macular degeneration, and glaucoma. Increasing evidence indicated that P2X7R is over-activated in retinopathy and is involved in the occurrence and development of diabetic retinopathy. Purine vasotoxicity caused by over-activation of P2X7R can lead to decreased retinal blood flow and vascular dysfunction and activation of P2X7R can lead to the production of a large number of inflammatory factors, causing local inflammatory cells to infiltrate and form a vascular microenvironment, thus constituting the pathophysiological basis for the occurrence and development of retinopathy. A variety of P2X7R antagonists have been studied in clinical trials as potential treatments for retinal diseases. However, currently no P2X7R antagonists has been approved for retina diseases. In this review, we mainly focus on recent progress on the involvement of P2X7R in retinal diseases and its therapeutic potential in the future.
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页数：9
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