Discovery of dietary beneficial compounds for healthy aging: From worm to human

被引：0

作者：

Ye, Xianjiang ^{[1
]}

Wang, Hao ^{[1
]}

Han, Yuxuan ^{[1
]}

Fu, Xing ^{[1
]}

Zhang, Jiuliang ^{[1
]}

Zhang, Tao ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Food Sci & Technol, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China

来源：

FOOD RESEARCH INTERNATIONAL | 2025年 / 218卷

基金：

中国国家自然科学基金;

关键词：

Aging; Dietary bioactive compounds; C; elegans; Lifespan; Clinical study; ORNITHINE ALPHA-KETOGLUTARATE; LIFE-SPAN EXTENSION; DOUBLE-BLIND TRIAL; CAENORHABDITIS-ELEGANS; C; ELEGANS; OXIDATIVE STRESS; CALORIC RESTRICTION; VITAMIN-D; AGE; RESVERATROL;

D O I：

10.1016/j.foodres.2025.116916

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Aging is marked by a decline in physiological functions and an increased susceptibility to neurodegenerative disorders. As the aging population rapidly expands, optimizing dietary nutrients has become a crucial strategy for promoting healthy aging. Bioactive compounds, abundant in dietary sources, offer a promising solution to reduce the risks of age-related diseases. Focusing on Caenorhabditis elegans (C. elegans) models and clinical research, this review synthesizes recent advances in understanding the anti-aging effects and mechanistic insights of dietary bioactive compounds, such as fisetin, quercetin, epicatechin, nobiletin, naringenin, nomilin, resveratrol, ergothioneine, coumarin, sesamin and oleic acid. By exploring the metabolic similarities between C. elegans and humans, we propose C. elegans model serves as a pioneer for discovering dietary anti-aging compounds, which enables high-throughput screening. This up-to-date summary of the anti-aging effect of dietary bioactive compounds has demonstrated powerful potential for promoting healthy aging in the human population. Future research should focus on elucidating the bioavailability, metabolic interactions, and synergistic effects of these bioactive compounds to facilitate their translation into effective dietary interventions.

引用

页数：16

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