Control of T-cell immunity by fatty acid metabolism

被引：0

作者：

Kim, Jaemin ^{[1
,2
]}

Lee, Yoosun ^{[1
,2
]}

Chung, Yeonseok ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Inst Pharmaceut Sci, Coll Pharm, Lab Immune Regulat, Seoul 08826, South Korea

[2] Seoul Natl Univ, Coll Pharm, Plus Program BK21, Seoul, South Korea

来源：

ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2024年 / 29卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Fatty acids; Fatty acid metabolism; Fatty acid signaling; Immunometa-; bolism; T-cell differentiation; REGULATORY T; DIFFERENTIATION; MICROBIOTA; EFFECTOR; MEMORY;

D O I：

10.6065/apem.2448160.080

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fatty acids play critical roles in maintaining the cellular functions of T cells and regulating T-cell immunity. This review synthesizes current research on the influence cells), and TFH (T follicular helper) cells. Fatty acids impact T cells by modulating signaling pathways, inducing metabolic changes, altering cellular structures, and regulating gene expression epigenetically. These processes affect T-cell activation, differentiation, and function, with implications for diseases such as autoimmune disease and cancer. Based on these insights, fatty acid pathways can potentially be modulated by novel therapeutics, paving the way for novel treatment approaches for immune-mediated disorders and cancer immunotherapy.

引用

页码：356 / 364

页数：9

共 59 条

[1] Metabolic Challenges in Anticancer CD8 T Cell Functions [J].

Amitrano, Andrea M. ;

Kim, Minsoo .

IMMUNE NETWORK, 2023, 23 (01)

[2] Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells [J].

Angela, Mulki ;

Endo, Yusuke ;

Asou, Hikari K. ;

Yamamoto, Takeshi ;

Tumes, Damon J. ;

Tokuyama, Hirotake ;

Yokote, Koutaro ;

Nakayama, Toshinori .

NATURE COMMUNICATIONS, 2016, 7

[3] De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells [J].

Berod, Luciana ;

Friedrich, Christin ;

Nandan, Amrita ;

Freitag, Jenny ;

Hagemann, Stefanie ;

Harmrolfs, Kirsten ;

Sandouk, Aline ;

Hesse, Christina ;

Castro, Carla N. ;

Baehres, Heike ;

Tschirner, Sarah K. ;

Gorinski, Nataliya ;

Gohmert, Melanie ;

Mayer, Christian T. ;

Huehn, Jochen ;

Ponimaskin, Evgeni ;

Abraham, Wolf-Rainer ;

Mueller, Rolf ;

Lochner, Matthias ;

Sparwasser, Tim .

NATURE MEDICINE, 2014, 20 (11) :1327-1333

[4]

Bi XY, 2017, J CLIN INVEST, V127, P1757, DOI [10.1172/JCI87388, 10.1172/jci87388]

[5] A two-step, two-signal model for the primary activation of precursor helper T cells [J].

Bretscher, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) :185-190

[6] Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids [J].

Cait, A. ;

Hughes, M. R. ;

Antignano, F. ;

Cait, J. ;

Dimitriu, P. A. ;

Maas, K. R. ;

Reynolds, L. A. ;

Hacker, L. ;

Mohr, J. ;

Finlay, B. B. ;

Zaph, C. ;

McNagny, K. M. ;

Mohn, W. W. .

MUCOSAL IMMUNOLOGY, 2018, 11 (03) :785-795

[7] Microbiota Metabolite Butyrate Differentially Regulates Th1 and Th17 Cells' Differentiation and Function in Induction of Colitis [J].

Chen, Liang ;

Sun, Mingming ;

Wu, Wei ;

Yang, Wenjing ;

Huang, Xiangsheng ;

Xiao, Yi ;

Ma, Chunyan ;

Xu, Leiqi ;

Yao, Suxia ;

Liu, Zhanju ;

Cong, Yingzi .

INFLAMMATORY BOWEL DISEASES, 2019, 25 (09) :1450-1461

[8] NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells [J].

Choi, Garam ;

Ju, Hye-Yeon ;

Bok, Jahyun ;

Choi, Jungseo ;

Shin, Jae Woo ;

Oh, Hansol ;

Jeon, Yeojin ;

Kim, Jiyeon ;

Kim, Daehong ;

Moon, Heesu ;

Lee, Jeong-Eun ;

Keum, Young-Sam ;

Kim, You-Me ;

Kim, Hye Young ;

Park, Sung Ho ;

Han, Mi-Ryung ;

Chung, Yeonseok .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 121 (28)

[9] Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis [J].

Cluxton, Deborah ;

Petrasca, Andreea ;

Moran, Barry ;

Fletcher, Jean M. .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[10] Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets [J].

Crow, Mary K. .

ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 (08) :999-1014

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