Targeting m6A RNA Modification in Tumor Therapeutics

被引：2

作者：

Mao, Zhenwei ^{[1
,2
]}

Li, Min ^{[1
,2
]}

Wang, Shengjun ^{[2
,3
]}

机构：

[1] Jiangsu Univ, Affiliated Peoples Hosp, Dept Lab Med, Zhenjiang 212002, Peoples R China

[2] Jiangsu Univ, Sch Med, Dept Immunol, Jiangsu Key Lab Lab Med, Zhenjiang 212002, Peoples R China

[3] Jiangsu Univ, Dept Lab Med, Affiliated Hosp, Zhenjiang 212001, Peoples R China

来源：

CURRENT ONCOLOGY | 2025年 / 32卷 / 03期

关键词：

N6-methyladenosine (m(6)A); mRNA; tumor; targeting therapy; METHYLTRANSFERASE METTL3 PROMOTES; MESSENGER-RNA; METHYLATED NUCLEOTIDES; CANCER; STEM; CELLS; DEMETHYLASE; EXPRESSION; DIFFERENTIATION; PROLIFERATION;

D O I：

10.3390/curroncol32030159

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prevalent eukaryotic RNA modification N6-methyladenosine (m(6)A), which is distributed in more than 50% of cases, has demonstrated significant implications in both normal development and disease progression, particularly in the context of cancer. This review aims to discuss the potential efficacy of targeting tumor cells through modulation of m(6)A RNA levels. Specifically, we discuss how the upregulation or downregulation of integral or specific targets is effective in treating different tumor types and patients. Additionally, we will cover the factors influencing the efficacy of m(6)A RNA targeting in tumor treatment. Our review will focus on the impact of targeting m(6)A mRNA on genes and cells and assess its potential as a therapeutic strategy for tumors. Despite the challenges involved, further research on m(6)A RNA in tumors and its integration with existing tumor therapy approaches is warranted.

引用

页数：27

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