1,2,3-Triazole-gold(I)-triethylphosphine derivatives of nutrients as new antimicrobials against antibiotic resistant Gram-positive pathogens

被引：0

作者：

Michaut, Mathieu ^{[4
]}

Hoegy, Francoise ^{[1
,2
]}

Steffen, Alexandre ^{[4
]}

Contreras, Jean-Marie ^{[4
]}

Morice, Christophe ^{[4
]}

Plesiat, Patrick ^{[3
]}

Mislin, Gaetan L. A. ^{[1
,2
]}

机构：

[1] CNRS, Biotechnol & Signalisat Cellulaire, UMR7242, 300 Blvd Sebastien Brant, F-67400 Illkirch Graffenstaden, France

[2] Univ Strasbourg, Inst Rech Ecole Biotechnol Strasbourg IREBS, F-67400 Illkirch Graffenstaden, France

[3] Univ Bourgogne Franche Comte, Lab Bacteriol, CNRS Chronoenvironm, UFR Sante,UMR 6249, Besancon, France

[4] PC SAS, Prestwick Chem, 220 Blvd Gonthier dAndernach, F-67400 Illkirch Graffenstaden, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2025年 / 125卷

关键词：

Antibiotic; Gold(I) complex; Azide-alkyne Huisgen cycloaddition; Clostridium difficile; Staphylococcus sp; Enterococcus sp; GOLD; COMPLEXES;

D O I：

10.1016/j.bmcl.2025.130276

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The ongoing rise of bacterial resistance against antibiotics is an incentive to develop radically new antibacterial molecules. Innovative organo-gold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine-gold(I) azides and alkyne-functionalized metabolites like amino acids, nicotinic acid and biotin. The resulting organo-gold(I) compounds exhibited remarkable activities against a panel of Gram-positive pathogens (Staphyloccocus sp., Enterococcus sp. and Clostridium difficile) but failed to inhibit the growth of Gram-negative bacilli (e.g., Escherichia coli) under the conditions used (8 mu g. mL-1 maximum).

引用

页数：5

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