Targeting tuberculosis with LNP-mRNA vaccines: opportunities, challenges and future directions

被引：0
作者：
Lukeman, Hannah [1 ,2 ]
Chan, Elizabeth [1 ,2 ]
Triccas, James [1 ,2 ]
机构：
[1] Univ Sydney, Sydney Infect Dis Inst Sydney ID, Fac Med & Hlth, Camperdown, NSW 2006, Australia
[2] Univ Sydney, Fac Med & Hlth, Sch Med Sci, Camperdown, NSW 2006, Australia
来源：
MICROBIOLOGY AUSTRALIA | 2025年 / 46卷 / 02期
基金：
英国医学研究理事会;
关键词：
cellular immunity; lipid nanoparticle; mRNA vaccine; mucosal immunity; Mycobacterium tuberculosis; preclinical studies; TB; tuberculosis; vaccination; PROTECTION;
D O I：
10.1071/MA25017
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tuberculosis (TB) remains one of the leading causes of infectious disease mortality, despite widespread use of the Bacillus Calmette-Gu & eacute;rin (BCG) vaccine. The COVID-19 pandemic demonstrated the potential of mRNA vaccines to induce rapid and robust immunity, leading to interest in their application against TB. However, developing an effective mRNA vaccine for TB presents unique challenges, including the need for strong cellular immune responses and lung-targeted immunity. This review explores the potential of lipid nanoparticle (LNP)-encapsulated mRNA vaccines to generate protective immune responses against Mycobacterium tuberculosis. We discuss recent advances in the field, including promising preclinical studies, and highlight key knowledge gaps that must be addressed before mRNA vaccines can be considered a viable option for TB control.
引用
收藏
页码：48 / 51
页数：4
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