Aortic diameter remodeling after frozen elephant trunk as a predictor of early outcomes in thoracoabdominal aortic repair

Objective: Patients who underwent previous frozen elephant trunk implantation for Stanford type A aortic dissection remain at risk for secondary intervention due to unsuccessful distal aortic remodeling. We aimed to investigate the impact of distal aortic remodeling on early outcomes in patients who underwent 2-stage thoracoabdominal aortic repair. Methods: A total of 106 patients who previously underwent frozen elephant trunk implantation and thoracoabdominal aortic repair between October 2014 and December 2022 were enrolled in this study. The extent of distal aortic remodeling was evaluated, including aortic diameter, area ratio of the false lumen/aortic lumen, and patency of the false lumen at 3 levels of the aorta. Logistic regression analyses were performed to investigate the risk factors for early outcomes. Results: The aortic diameter at the distal frozen elephant trunk was significantly larger in patients who died early than in surviving patients (79.19 +/- 22.89 mm vs 46.84 +/- 19.17 mm, respectively, adjusted P = .001). The optimal cutoff value for the aortic diameter at the distal frozen elephant trunk was 60 mm. Patients with an aortic diameter 60 mm or more at the distal frozen elephant trunk had worse early outcomes (P <.05), including prolonged intubation, early death, and postoperative complications. The aortic diameter at the distal frozen elephant trunk was identified as a significant risk factor for early death in patients undergoing thoracoabdominal aortic repair. Conclusions: Patients undergoing thoracoabdominal aortic repair with an aortic diameter 60 mm or more at the distal frozen elephant trunk have worse early outcomes. Moreover, an aortic diameter at the distal frozen elephant trunk is a significant risk factor for early death in patients undergoing thoracoabdominal aortic repair. (J Thorac Cardiovasc Surg 2025;169:1663-74)