Exercise Training, Cardiac Biomarkers, and Cardiorespiratory Fitness in Type 2 Diabetes The HART-D Study

被引：4
作者：
Patel, Kershaw V. [1 ]
Saha, Amit [2 ]
Ayers, Colby R. [2 ]
Rohatgi, Anand [2 ]
Berry, Jarett D. [2 ]
Almandoz, Jaime P. [2 ]
Johannsen, Neil M. [3 ]
Defilippi, Christopher [4 ]
Church, Timothy S. [5 ]
de Lemos, James A. [2 ]
Pandey, Ambarish [2 ]
机构：
[1] Houston Methodist DeBakey Heart & Vasc Ctr, Dept Cardiol, Houston, TX USA
[2] Univ Texas Southwestern Med Ctr, Dept Internal Med, Div Cardiol, Dallas, TX USA
[3] Louisiana State Univ, Coll Human Sci & Educ, Sch Kinesiol, Baton Rouge, LA USA
[4] Inova Heart & Vasc Inst, Falls Church, VA USA
[5] Pennington Biomed Res Ctr, Prevent Med Lab, Baton Rouge, LA USA
来源：
JACC-ADVANCES | 2023年 / 2卷 / 01期
基金：
美国国家卫生研究院;
关键词：
exercise training; high-sensitivity cardiac troponin T; N-terminal pro-B-type natriuretic peptide; type; 2; diabetes; BRAIN NATRIURETIC PEPTIDE; LIFE-STYLE INTERVENTION; HIGHLY SENSITIVE ASSAY; INCIDENT HEART-FAILURE; TROPONIN-T; PHYSICAL-ACTIVITY; ATHEROSCLEROSIS RISK; CARDIOVASCULAR EVENTS; HEMOGLOBIN A(1C); OBESE ADULTS;
D O I：
10.1016/j.jacadv.2022.100174
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUND High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are cardiac biomarkers commonly detected in adults with type 2 diabetes (T2D) and are associated with heart failure risk. OBJECTIVES The purpose of this study was to evaluate the effects of exercise training (ET) on hs-cTnT and NT-proBNP and evaluate the associations of these biomarkers with cardiorespiratory fitness among adults with T2D. METHODS Participants of the HART-D (Health Benefits of Aerobic and Resistance Training in Individuals with Type 2 Diabetes) trial who were randomly assigned to one of 3 ET groups or a non-exercise control group were included. Cardiac biomarkers and cardiorespiratory fitness (evaluated by peak oxygen uptake [VO2peak]) were assessed at baseline and after 9 months. The effects of ET (3 ET groups pooled) vs non-exercise control on hs-cTnT and NT-proBNP were assessed using separate analysis of covariance models. Multivariable-adjusted linear regression was performed to identify factors associated with follow-up biomarkers and 0VO2peak. RESULTS The present study included 166 participants randomized to the ET (n =135) and non-exercise control (n = 31) groups. Compared with the non-exercise control, ET did not significantly change hs-cTnT or NT-proBNP. In adjusted analysis, each ET group and 0VO2peak were not significantly associated with hs-cTnT or NT-proBNP levels on follow-up. Among individuals in the ET group, baseline hs-cTnT was inversely associated with 0VO2peak [per 1 SD higher log (hs-cTnT): b =-0.08 (95% CI =-0.15 to-0.01)]. CONCLUSIONS Among individuals with T2D, ET did not modify cardiac biomarkers. Higher baseline hs-cTnT was associated with blunted cardiorespiratory fitness improvement in response to exercise. (JACC Adv 2023;2:100174) (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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页数：10
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