RNA structure prediction using deep learning — A comprehensive review

In computational biology, accurate RNA structure prediction offers several benefits, including facilitating a better understanding of RNA functions and RNA-based drug design. Implementing deep learning techniques for RNA structure prediction has led tremendous progress in this field, resulting in significant improvements in prediction accuracy. This comprehensive review aims to provide an overview of the diverse strategies employed in predicting RNA secondary structures, emphasizing deep learning methods. The article categorizes the discussion into three main dimensions: feature extraction methods, existing state-of-the-art learning model architectures, and prediction approaches. We present a comparative analysis of various techniques and models highlighting their strengths and weaknesses. Finally, we identify gaps in the literature, discuss current challenges, and suggest future approaches to enhance model performance and applicability in RNA structure prediction tasks. This review provides a deeper insight into the subject and paves the way for further progress in this dynamic intersection of life sciences and artificial intelligence. © 2025 The Authors