Multiple Myeloma Unpacked

被引：0

作者：

Gay, Francesca ^{[1
]}

Marchetti, Edoardo ^{[1
]}

Bertuglia, Giuseppe ^{[1
]}

机构：

[1] Univ Torino, Dept Mol Biotechnol & Hlth Sci, Div Hematol, AOU Citta Salute & Sci, Turin, Italy

来源：

HEMATOLOGICAL ONCOLOGY | 2025年 / 43卷

关键词：

immunotherapies; myeloma; response assessment; staging; TRANSPLANT-INELIGIBLE PATIENTS; DARATUMUMAB PLUS LENALIDOMIDE; INTERNATIONAL STAGING SYSTEM; NDMM UPDATED ANALYSIS; T-CELL THERAPY; OPEN-LABEL; CILTACABTAGENE AUTOLEUCEL; DEXAMETHASONE; CARFILZOMIB; BORTEZOMIB;

D O I：

10.1002/hon.70067

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells in the bone marrow. The current treatment landscape for multiple myeloma involves a combination of proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies, and autologous stem cell transplantation, which have significantly improved survival outcomes in recent years. However, the disease remains challenging, particularly in relapsed and refractory cases. Ongoing clinical trials are evaluating new therapeutic options, including chimeric antigen receptor T cell therapy, bispecific antibodies, antibody drug conjugate and novel agents like Cereblon E3 Ligase Modulatory Drugs. This review summarizes the key diagnostic criteria, prognostic features, response assessment for MM and highlights the current treatment landscape.

引用

页数：14

共 97 条

[71] A Phase II Trial of the Combination of Ixazomib, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma [J].

Nadeem, Omar ;

Reed, Robert A. ;

Prescott, Julia ;

Tague, Kelsey ;

Romines, Veronica ;

Metivier, Amada ;

Savell, Alexandra ;

Leblebjian, Houry ;

Distaso, Alexandra ;

Mo, Clifton C. ;

Laubach, Jacob P. ;

Sperling, Adam S. ;

Richardson, Paul G. ;

Ghobrial, Irene M. .

BLOOD, 2021, 138

[72] The significance of free light-chain ratio in light-chain monoclonal gammopathy of undetermined significance: a flow cytometry sub-study of the iStopMM screening study [J].

Oskarsson, Jon Thorir ;

Rognvaldsson, Saemundur ;

Thorsteinsdottir, Sigrun ;

Long, Thorir Einarsson ;

Olafsson, Andri ;

Eythorsson, Elias ;

Jonsson, Asbjorn ;

Vioarsson, Brynjar ;

Onundarson, Pall T. ;

Agnarsson, Bjarni A. ;

Palmason, Robert ;

Siguroardottir, Margret ;

Thorsteinsdottir, Ingunn ;

Olafsson, Isleifur ;

Harding, Stephen J. ;

Durie, Brian G. M. ;

Love, Thorvardur Jon ;

Kristinsson, Sigurdur Y. .

BLOOD CANCER JOURNAL, 2024, 14 (01)

[73] Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group [J].

Palumbo, Antonio ;

Avet-Loiseau, Herve ;

Oliva, Stefania ;

Lokhorst, Henk M. ;

Goldschmidt, Hartmut ;

Rosinol, Laura ;

Richardson, Paul ;

Caltagirone, Simona ;

Jose Lahuerta, Juan ;

Facon, Thierry ;

Bringhen, Sara ;

Gay, Francesca ;

Attal, Michel ;

Passera, Roberto ;

Spencer, Andrew ;

Offidani, Massimo ;

Kumar, Shaji ;

Musto, Pellegrino ;

Lonial, Sagar ;

Petrucci, Maria T. ;

Orlowski, Robert Z. ;

Zamagni, Elena ;

Morgan, Gareth ;

Dimopoulos, Meletios A. ;

Durie, Brian G. M. ;

Anderson, Kenneth C. ;

Sonneveld, Pieter ;

San Miguel, Jesus ;

Cavo, Michele ;

Rajkumar, S. Vincent ;

Moreau, Philippe .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (26) :2863-+

[74] Cereblon E3 Ligase Modulators Mezigdomide and Iberdomide in Multiple Myeloma [J].

Patel, Tanvi H. ;

van Rhee, Frits ;

Al Hadidi, Samer .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2024, 24 (11) :762-769

[75]

Raab MS, 2024, BLOOD, V144, P493, DOI [10.1182/blood-2024-206003, 10.1182/blood-2024-206003]

[76] International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma [J].

Rajkumar, S. Vincent ;

Dimopoulos, Meletios A. ;

Palumbo, Antonio ;

Blade, Joan ;

Merlini, Giampaolo ;

Mateos, Maria-Victoria ;

Kumar, Shaji ;

Hillengass, Jens ;

Kastritis, Efstathios ;

Richardson, Paul ;

Landgren, Ola ;

Paiva, Bruno ;

Dispenzieri, Angela ;

Weiss, Brendan ;

Leleu, Xavier ;

Zweegman, Sonja ;

Lonial, Sagar ;

Rosinol, Laura ;

Zamagni, Elena ;

Jagannath, Sundar ;

Sezer, Orhan ;

Kristinsson, Sigurdur Y. ;

Caers, Jo ;

Usmani, Saad Z. ;

Lahuerta, Juan Jose ;

Johnsen, Hans Erik ;

Beksac, Meral ;

Cavo, Michele ;

Goldschmidt, Hartmut ;

Terpos, Evangelos ;

Kyle, Robert A. ;

Anderson, Kenneth C. ;

Durie, Brian G. M. ;

San Miguel, Jesus F. .

LANCET ONCOLOGY, 2014, 15 (12) :E538-E548

[77] Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma [J].

Richardson, P. G. ;

Trudel, S. ;

Popat, R. ;

Mateos, M-, V ;

Vangsted, A. J. ;

Ramasamy, K. ;

Martinez-Lopez, J. ;

Quach, H. ;

Orlowski, R. Z. ;

Arnao, M. ;

Lonial, S. ;

Karanes, C. ;

Pawlyn, C. ;

Kim, K. ;

Oriol, A. ;

Berdeja, J. G. ;

Rodriguez Otero, P. ;

Casas-Aviles, I ;

Spirli, A. ;

Poon, J. ;

Li, S. ;

Gong, J. ;

Wong, L. ;

Lamba, M. ;

Pierce, D. W. ;

Amatangelo, M. ;

Peluso, T. ;

Maciag, P. ;

Katz, J. ;

Pourdehnad, Michael ;

Bahlis, Nizar J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 389 (11) :1009-1022

[78]

Richardson PG, 2024, HAEMATOLOGICA, V109, P2239, DOI 10.3324/haematol.2023.284325

[79] Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial [J].

Richardson, Paul G. ;

Oriol, Albert ;

Beksac, Meral ;

Liberati, Anna Marina ;

Galli, Monica ;

Schjesvold, Fredrik ;

Lindsay, Jindriska ;

Weisel, Katja ;

White, Darrell ;

Facon, Thierry ;

Miguel, Jesus Son ;

Sunami, Kazutaka ;

O'Gorman, Peter ;

Sonneveld, Pieter ;

Robak, Pawel ;

Semochkin, Sergey ;

Schey, Steve ;

Yu, Xin ;

Doerr, Thomas ;

Bensmaine, Amine ;

Biyukov, Tsvetan ;

Peluso, Teresa ;

Zaki, Mohamed ;

Anderson, Kenneth ;

Dimopoulos, Meletios .

LANCET ONCOLOGY, 2019, 20 (06) :781-794

[80] Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma [J].

Rodriguez-Otero, Paula ;

Ailawadhi, Sikander ;

Arnulf, Bertrand ;

Patel, Krina ;

Cavo, Michele ;

Nooka, Ajay K. ;

Manier, Salomon ;

Callander, Natalie ;

Costa, Luciano J. ;

Vij, Ravi ;

Bahlis, Nizar J. ;

Moreau, Philippe ;

Solomon, Scott R. ;

Delforge, Michel ;

Berdeja, Jesus ;

Truppel-Hartmann, Anna ;

Yang, Zhihong ;

Favre-Kontula, Linda ;

Wu, Fan ;

Piasecki, Julia ;

Cook, Mark ;

Giralt, Sergio .

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388 (11) :1002-1014

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