Single nucleotide variants of the SLC2A2 gene in Mexican-origin population

被引：0

作者：

Gutierrez-Garcia, Christopher A. ^{[1
]}

Gutierrez-Jimenez, Martin R. ^{[1
]}

Sandoval-Muniz, Roberto de J. ^{[2
]}

Baptista-Rosas, Raul C. ^{[1
,3
]}

机构：

[1] Univ Guadalajara, Ctr Univ Tonala, Guadalajara, Jalisco, Mexico

[2] Secretaria Salud Jalisco, Reg Sanitaria Tonala Capacitac 11, Guadalajara, Jalisco, Spain

[3] Hosp Gen Occidente Seguro Social, Guadalajara, Jalisco, Mexico

来源：

GACETA MEDICA DE MEXICO | 2025年 / 161卷 / 01期

关键词：

Type 2 Diabetes mellitus; Mexican people; Single nucleotide polymorphisms; Glucose transporter type 2; Single nucleotide variants; GLUCOSE-TRANSPORTER GENE; GLUT2; MUTATIONS; ASSOCIATION; POLYMORPHISMS; SNPS;

D O I：

10.24875/GMM.24000293

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Diabetes, which is caused by environmental and genetic factors, has a high global prevalence (10.5%). Some single nucleotide variants (SNVs) modify the activity of glucose transporters such as GLUT2, which plays a significant role in insulin secretion and glucose metabolism. Objective: To analyze the SNVs associated with type 2 diabetes (T2D) in the Mexican population. Material and methods: Reference databases for SNVs registered for SLC2A2 gen associated with T2D in the Mexican population. Results. 83 SNVs were analyzed, identifying 3 relevant variants in Mexican population associated with T2D: rs5404, rs5406 and rs5398, a pathogenic variant with RM >1.0 and p value < 0.05. Conclusions: Detailed genetic analysis and mapping coupled with functional studies are needed to identify the mechanism by which GLUT2 variants influence diabetes development.

引用

页码：108 / 115

页数：8

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