Genetic testing and Guangdong college students in China: A cross-sectional study of knowledge and attitudes

被引：0

作者：

Wang, Jiaming ^{[1
,2
]}

Lin, Ruoru ^{[1
,3
]}

Luo, Sijing ^{[1
,4
]}

Zhong, Beilei ^{[1
,5
]}

Zhu, Yurang ^{[1
,6
]}

Huang, Jiayi ^{[1
,7
]}

Zhang, Dangui ^{[8
]}

Ba-Thein, William ^{[9
,10
]}

机构：

[1] Shantou Univ, Med Coll, Undergraduate Res Training Program UGRTP, Shantou, Peoples R China

[2] Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Peoples R China

[3] Jinan Univ, Sch Stomatol, Guangzhou, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Cardiovasc Med, Guangzhou, Peoples R China

[5] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China

[6] Jinan Univ, Affiliated Hosp 1, Dept Gynecol & Obstet, Guangzhou, Peoples R China

[7] Southern Med Univ, Guangzhou, Peoples R China

[8] Shantou Univ, Affiliated Hosp 2, Res Ctr Translat Med, Med Coll, Dongxia Rd 69, Shantou 515041, Peoples R China

[9] Shantou Univ, Med Coll, Clin Res Unit, Xinling Rd 22, Shantou 515041, Peoples R China

[10] Shantou Univ, Med Coll, Dept Microbiol & Immunol, Xinling Rd 22, Shantou 515041, Peoples R China

来源：

PREVENTIVE MEDICINE REPORTS | 2025年 / 56卷

关键词：

Direct-to-consumer genetic tests; Informed consent; Functional health literacy; College students; China;

D O I：

10.1016/j.pmedr.2025.103133

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: This study investigated functional health literacy and attitudes toward genetic testing among Chinese college students to understand if they can make informed decisions and avoid potential risks. Methods: A cross-sectional anonymous online survey was conducted with students from 13 colleges in Guangdong province during October-November 2021. Results: Of the 1543 participants, 53.9 % were female, predominantly undergraduates (97.2 %). Most students reported being health-conscious (76.6 %), less religious (60.3 %), possessing health esteem (76.4 %), and having parents in non-healthcare occupations (89.1 %). The median score for functional genetic literacy was 10 out of 17. Most (91.4 %) expressed positive attitudes toward genetic testing, with 65.1 % favoring direct-to-consumer options. The most preferred tests were predictive (83.3 %) and premarital/preconception tests (76.4 %). Multiple linear regression analysis showed independent predictors of functional genetic literacy as female gender (Beta, 95 %CI: 0.26, 0.02-0.49), medicine major (1.51, 1.27-1.74), health-esteem personality trait (0.34, 0.06-0.62), lower religiosity (0.66, 0.49-0.83), and lower perceived financial status (0.47, 0.21-0.73). Logistic regression analysis identified independent predictors of positive attitude toward genetic testing as self-respect personality (adjusted odds ratio, 95 %CI: 1.81, 1.23-2.66), lower perceived financial status (0.57, 0.38-0.83), and parental occupation in non-healthcare (0.38, 0.17-0.89). Conclusions: Guangdong college students were mostly positive toward genetic testing, particularly predictive and premarital options. However, their limited functional genetic testing literacy may hinder informed decision-making. To address ethical, legal, and social implications, China should strengthen public education, promote the genetic counseling profession and enhance regulatory oversight in the genetic testing industry.

引用

页数：7

共 34 条

[1] Does high self-esteem cause better performance, interpersonal success, happiness, or healthier lifestyles? [J].