Co-infection with hepatitis B and human immunodeficiency virus: epidemiology, pathogenesis, and treatment

被引：1
作者：
He, Yaozu [1 ,2 ]
Lin, Weiyin [1 ,2 ]
Gu, Fei [1 ,2 ]
Lan, Xianglong [1 ,2 ]
Li, Linghua [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou Med Res Inst Infect Dis, Guangzhou 510060, Peoples R China
[2] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Infect Dis Ctr, Guangzhou 510060, Peoples R China
来源：
INFECTIOUS DISEASES & IMMUNITY | 2025年 / 5卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Hepatitis B virus; HIV; Pathogenesis; Antiretroviral therapy; Functional cure; T-CELL RESPONSES; ANTIRETROVIRAL THERAPY; HBV INFECTION; HIV; MORTALITY; RISK; INTERFERON; PREVALENCE; MEN;
D O I：
10.1097/ID9.0000000000000123
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Co-infection with hepatitis B virus (HBV) and human immunodeficiency virus (HIV) is common as the modes of disease transmission are similar. HIV affects the development of chronic HBV infection, leading to higher HBV DNA levels, cirrhosis, and end-stage liver duisease, and potentially leading to hepatocellular carcinoma. One of the leading causes of mortality and morbidity in HIV-infected individualsis liver disease, despite the administration of antiretroviral therapy for HIV and HBV. Thus, the screening and follow-up of co-infected patients are vital formonitoring of liver disease progression. This study reviews the natural history and pathogenesis of liver disease in the context of HBV/HIV co-infection, current treatments for HBV in patients with HIV, and treatment outcomes in coinfected individuals.
引用
收藏
页码：56 / 61
页数：6
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