The evolving neurobiology of early-life stress

被引：4
作者：
Birnie, Matthew T. [1 ]
Baram, Tallie Z. [1 ,2 ,3 ]
机构：
[1] Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA
[2] Univ Calif Irvine, Dept Anat Neurobiol, Irvine, CA 92717 USA
[3] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA
来源：
NEURON | 2025年 / 113卷 / 10期
关键词：
CORTICOTROPIN-RELEASING HORMONE; ADVERSE CHILDHOOD EXPERIENCES; PITUITARY-ADRENAL AXIS; CRITICAL-PERIOD; PSYCHIATRIC-DISORDERS; HOUSEHOLD DYSFUNCTION; MOLECULAR-MECHANISMS; BASOLATERAL AMYGDALA; SOCIOECONOMIC-STATUS; COGNITIVE DEFICITS;
D O I：
10.1016/j.neuron.2025.02.016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Because early-life stress is common and constitutes a strong risk factor for cognitive and mental health disorders, it has been the focus of a multitude of studies in humans and experimental models. Yet, we have an incomplete understanding of what is perceived as stressful by the developing brain, what aspects of stress influence brain maturation, what developmental ages are particularly vulnerable to stress, which molecules mediate the effects of stress on brain operations, and how transient stressful experiences can lead to enduring emotional and cognitive dysfunctions. Here, we discuss these themes, highlight the challenges and progress in resolving them, and propose new concepts and avenues for future research.
引用
收藏
页码：1474 / 1490
页数：17
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