Determination of five alkylhydrazines by isotope-coded derivatization combined with ultra-high-performance liquid chromatography-tandem mass spectrometry

被引：0

作者：

Xu, Zenghui ^{[1
]}

Lu, Zhihao ^{[1
]}

Yu, Shuiqiang ^{[1
]}

Sun, Zhiwei ^{[1
]}

You, Jinmao ^{[1
,2
]}

机构：

[1] Qufu Normal Univ, Key Lab Life Organ Anal Shandong Prov, Qufu 273165, Peoples R China

[2] Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2025年 / 494卷

关键词：

UHPLC-MS/MS; Alkylhydrazines; Isotope-coded derivatization; HYDRAZINE; 1,1-DIMETHYLHYDRAZINE; METHYLHYDRAZINE; EXPOSURE; PLASMA; HPLC;

D O I：

10.1016/j.jhazmat.2025.138723

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Alkylhydrazines, extensively used in agricultural and military applications, pose notable environmental and health concerns due to their toxicity and potential accumulation in food chains. A novel isotope-coded derivatization (ICD) method was developed using 4-(N-methylphenanthroimidazolyl)-benzaldehyde as the reagent, enabling precise quantification of five alkylhydrazines in environmental and food matrices using ultra-high-performance liquid chromatographytandem mass spectrometry. The detection limits (0.008-0.033 mu g/L) were successfully improved with the derivatization method, and the relative standard deviations were < 3 %. The ICD reagent effectively eliminated matrix effects. Dimethylhydrazine was successfully detected in food samples within the range of 20.9-25.1 mu g/kg in fresh mushrooms.

引用

页数：10

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