A selective "off-on" rhodamine-based chemosensor for the detection of Cu2+ ions: colorimetric, theoretical and biological study

被引：0

作者：

Sarkar, Soma ^{[1
]}

Chatterjee, Abhik ^{[1
]}

Ghosh, Kingkar ^{[2
]}

Ghosh, Narendra Nath ^{[3
]}

Dutta, Ankita ^{[4
]}

Kumar, Anoop ^{[4
]}

Mandal, Amit Kumar ^{[5
]}

Biswas, Kinkar ^{[2
]}

机构：

[1] Raiganj Univ, Dept Chem, Design Synth & Simulat Lab, Uttar Dinajpur 733134, W Bengal, India

[2] Univ North Bengal, Dept Chem, Darjeeling 734013, W Bengal, India

[3] Pakuahat ANM High Sch, Malda 732138, W Bengal, India

[4] Univ North Bengal, Dept Biotechnol, Darjeeling 734013, W Bengal, India

[5] Raiganj Univ, Dept Sericulture, Chem Biol Lab, Uttar Dinajpur 733134, W Bengal, India

来源：

NEW JOURNAL OF CHEMISTRY | 2025年 / 49卷 / 25期

关键词：

COPPER; SENSOR; FLUORESCENT; ALZHEIMERS;

D O I：

10.1039/d5nj00410a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, an "off-on" chemosensor (RH) based on a rhodamine moiety was synthesized, which exhibited selective detection towards Cu2+ ions based on the spirocyclic ring-opening mechanism of the rhodamine unit. The chemosensor (RH) was colourless owing to intramolecular spirocyclization. In the presence of Cu2+ ions, the ring opening of RH occurred via complex formation, as observed in UV-Vis spectra. The absorption maxima shifted to 556 nm accompanied by an intense visible pink colour of the RH solution. RH showed high selectivity towards Cu2+ ions over other metal ions, and the limit of detection (LOD) was calculated to be 2.75 mu M. Quantum chemical calculations validated the formation of RH@Cu2+. The chemosensor also showed good cell viability and low cell cytotoxicity toward ACHN and HEK-293 cell lines.

引用

页码：10991 / 11000

页数：10

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