Precision peptide disruptors: The next generation of targeted therapeutics in oncology

被引：0

作者：

O'Gorman, Bria ^{[1
]}

Cooke, Sean F. ^{[1
]}

Blair, Connor M. ^{[1
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Scotland

来源：

CELLULAR SIGNALLING | 2025年 / 132卷

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

Peptide disruptors; Protein-protein interactions; Precision medicine; Oncology; TRANSCRIPTION FACTOR; CANCER; PCNA; ANTAGONIST; PHOSPHORYLATION; INHIBITION; EXPRESSION; MIMICKING; THERAPY; PATHWAY;

D O I：

10.1016/j.cellsig.2025.111783

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Therapeutically targeting the pathologically remodelled protein-protein interaction network in cancer with peptide disruptors increasingly represents a clinically attractive approach to treating recalcitrant cancers. In this review, we map the pre-clinical and clinical-stage peptide disruptor landscape within an oncology-specific context and discuss key clinical examples that are making significant impact to patients; demonstrating a key role for peptide disruptors in precision medicine as a next-generation targeted therapeutic.

引用

页数：8

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