The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases

被引：0
作者：
Abdel-Magid, Ahmed F.
机构：
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2025年 / 16卷 / 06期
关键词：
D O I：
10.1021/acsmedchemlett.5c00274
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The invention in this patent application relates to pyrazolo[1,5-a]pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and may be useful for the treatment of inflammatory, allergic, and autoimmune diseases. They can additionally be of potential relevance in treatment of cancer, metabolic diseases, bone density dysregulation diseases, pigmentation-related diseases or cosmetology, fibrotic diseases, and depressive disorders.
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页码：952 / 954
页数：3
相关论文
共 5 条
[1]   Roles of salt-inducible kinases in cancer (Review) [J].
Feng, Shenghui ;
Wei, Fangyi ;
Shi, Haoran ;
Chen, Shen ;
Wang, Bangqi ;
Huang, Deqiang ;
Luo, Lingyu .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2023, 63 (05)
[2]  
Jagannath A, 2023, PHYSIOL REV, V103, P2231, DOI 10.1152/physrev.00023.2022
[3]   Salt-inducible kinases (SIKs) in cancer: mechanisms of action and therapeutic prospects [J].
Manoharan, Ravi .
DRUG DISCOVERY TODAY, 2025, 30 (01)
[4]   Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo [J].
Sundberg, Thomas B. ;
Liang, Yanke ;
Wu, Huixian ;
Choi, Hwan Geun ;
Kim, Nam Doo ;
Sim, Taebo ;
Johannessen, Liv ;
Petrone, Adam ;
Khor, Bernard ;
Graham, Daniel B. ;
Latorre, Isabel J. ;
Phillips, Andrew J. ;
Schreiber, Stuart L. ;
Perez, Jose ;
Shamji, Alykhan F. ;
Gray, Nathanael S. ;
Xavier, Ramnik J. .
ACS CHEMICAL BIOLOGY, 2016, 11 (08) :2105-2111
[5]   Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential [J].
Wein, Marc N. ;
Foretz, Marc ;
Fisher, David E. ;
Xavier, Ramnik J. ;
Kronenberg, Henry M. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2018, 29 (10) :723-735
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