Impact of opium on bladder cancer incidence: A systematic review and meta-analysis

被引:0
作者
Mancon, S. [1 ,2 ,3 ]
Matsukawa, A. [1 ,4 ]
Cadenar, A. [1 ,5 ]
Tsuboi, I. [1 ,6 ]
Miszczyk, M. [1 ,7 ]
Parizi, M. K. [1 ,8 ]
Fazekas, T. [1 ,9 ]
Schulz, R. J. [1 ,10 ]
Cormio, A. [1 ,11 ]
Laukhtina, E. [1 ]
Gallioli, A. [12 ,13 ]
Diana, P. [12 ,13 ]
Contieri, R. [14 ]
Soria, F. [15 ]
Pradere, B. [16 ]
Lughezzani, G. [2 ,3 ]
Kimura, T. [4 ]
Territo, A. [12 ,13 ]
Breda, A. [12 ,13 ]
Buffi, N. M. [2 ,3 ]
Hurle, R. [3 ]
Shariat, S. F. [1 ,9 ,17 ,18 ,19 ,20 ,21 ,22 ,23 ]
D'Andrea, D. [1 ]
机构
[1] Univ Med Viena, Comprehens Canc Ctr, Dept Urol, Viena, Austria
[2] Univ Humanitas, Dept Ciencias Biomed, Pieve Emanuele, Italy
[3] IRCCS Humanitas Res Hosp, Dept Urol, Milan, Italy
[4] Univ Jikei, Escuela Med, Dept Urol, Tokyo, Japan
[5] Univ Florencia, Hosp Careggi, Dept Med Expt & Clin, Unidad Urol Oncol Minimamente Invas & Androl, Florencia, Italy
[6] Univ Shimane, Fac Med, Dept Urol, Matsue, Shimane, Japan
[7] Univ WSB, Fac Med, Coll Med, Dabrowa Gornicza, Poland
[8] Univ Ciencias Med Teheran, Hosp Shariati, Dept Urol, Tehran, Iran
[9] Ctr Med Univ Hamburgo Eppendorf, Dept Urol, Hamburgo, Germany
[10] Univ Semmelweis, Dept Urol, Budapest, Hungary
[11] Univ Politecn Marche, Azienda Osped Univ Osped Riuniti Ancona, Dept Urol, Ancona, Italy
[12] Fdn Puigvert, Serv Urol, Barcelona, Spain
[13] Univ Autonoma Barcelona, Dept Cirug, Bellaterra, Spain
[14] Ist Nazl Tumori IRCCS Fdn G Pascale, Dept Urol, Naples, Italy
[15] Escuela Med Turin, AOU Citta Salute & Sci, Dept Urol, Turin, Italy
[16] Hosp Croix Sud, Dept Urol, Quint Fonsegrives, France
[17] Univ Sechenov, Inst Urol & Salud Reprod, Moscu, Russia
[18] Ctr Med Univ Texas Southwestern, Dept Urol, Dallas, TX USA
[19] Fac Med Weill Cornell, Dept Urol, Nueva York, NY USA
[20] Univ Charles, Segunda Fac Med, Dept Urol, Prague, Czech Republic
[21] Univ Jordania, Dept Cirug Especial, Div Urol, Amman, Jordan
[22] Inst Karl Landsteiner Urol Androl, Viena, Austria
[23] Univ Ciencias Med Tabriz, Ctr Invest Med Basada Evidencia, Dept Urol, Tabriz, Iran
来源
ACTAS UROLOGICAS ESPANOLAS | 2025年 / 49卷 / 05期
关键词
Bladder cancer; Opium; Cancer; Incidence; Meta-analysis; RISK-FACTOR; TOBACCO USE; CONSUMPTION; SMOKING;
D O I
10.1016/j.acuro.2025.501749
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Opium is used recreationally and for pain relief in certain regions and has been classified as a human carcinogen by the IARC. While its use is rare in Europe and Oceania, it remains a major public health issue in other parts of the world. This study evaluates the risk of bladder cancer among opium users compared to non-users. Methods: A comprehensive search of MEDLINE, Scopus, and Web of Science was conducted up to July 2024 to identify studies examining the link between opium use and bladder cancer. A meta-analysis was performed to calculate the pooled risk ratio with 95% confidence intervals (CI) (PROSPERO: CRD42024562623). Results: A total of 15 studies (n = 60,149) were included. The analysis showed that opium users had a significantly higher risk of developing bladder cancer than non-users (risk ratio: 2.36; 95% CI: 1.92-2.90; P < 0.001). The risk increased with the amount of opium consumed, regardless of type or method of use. Conclusions: Opium consumption increase the risk of developing bladder cancer by more than twofold among users. Awareness of its carcinogenic potential and public health implications is crucial. Our findings underscore the need for global prevention strategies and further research into opium-related bladder cancer risks. (c) 2025 AEU. Published by Elsevier Espana, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
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页数:13
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