Cell-Based Therapeutic Strategies for Autoimmune Diseases

被引：0

作者：

Quero, Francisco B. ^{[1
]}

Troncoso-Bravo, Tays ^{[1
]}

Farias, Monica A. ^{[1
]}

Kalergis, Alexis M. ^{[1
,2
]}

机构：

[1] Pontificia Univ Catolica Chile, Millennium Inst Immunol & Immunotherapy, Fac Ciencias Biol, Av Portugal 49, Santiago E-8330025, Chile

[2] Pontificia Univ Catolica Chile, Fac Med, Dept Endocrinol, Santiago, Chile

来源：

IMMUNOTARGETS AND THERAPY | 2025年 / 14卷

关键词：

autoimmunity; cell therapy; CAR T cell; tolerogenic dendritic cell; regulatory T cell; stem cells; TOLEROGENIC DENDRITIC CELLS; REGULATORY T-CELLS; MESSENGER-RNA VACCINE; RHEUMATOID-ARTHRITIS; TREG CELLS; TRANSPLANTATION; MODULATION; GENERATION; DIFFERENTIATION; DISRUPTION;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Currently, the management of autoimmune disorders still being a challenge in terms of safety, efficiency, and specificity. Cell-based therapeutic strategies have emerged as a novel approach for autoimmune disease treatment, employing different cell therapy platforms, including tolerogenic dendritic cells, regulatory T cells, conventional and regulatory chimeric antigen receptor-T cells, mesenchymal and hematopoietic stem cells, each with their biological features. Here, we discuss the different cell therapy platforms, their immunological mechanisms of action, their therapeutic potential and benefits in autoimmune diseases, and challenges related to their production, scaling up, risks, and patient safety.

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页码：501 / 514

页数：14

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