Neuromodulatory Steroid Metabolites From the Sponge Topsentia sp.

被引：0

作者：

Cai, Lijuan ^{[1
]}

Zhou, Luyu ^{[1
]}

Xi, Chuchu ^{[2
,3
]}

Ren, Kerui ^{[2
,3
]}

Cheng, Zezhong ^{[1
]}

Cao, Zhengyu ^{[2
,3
]}

Han, Hua ^{[1
]}

Zhang, Wen ^{[1
,4
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai, Peoples R China

[2] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Nanjing, Peoples R China

[3] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept TCM Pharmacol, Nanjing, Peoples R China

[4] Peking Univ, Ningbo Inst Marine Med, Ningbo, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2025年

关键词：

chemotaxonomic significance; neuronal modulatory activity; steroid; Topsentia sp; INHIBITORY NATURAL-PRODUCTS; MARINE SPONGE; SIDE-CHAINS; HALISTANOL SULFATE; 24-ISOPROPYLCHOLESTEROL; TRISULFATE; IDENTIFICATION; INVERTEBRATES; DERIVATIVES; ALKALOIDS;

D O I：

10.1002/cbdv.202500265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two steroids (1, 2) and four steroid sulfates (3-6) were isolated from the sponge Topsentia sp. collected from the South China Sea. The structures of these compounds were determined based on spectroscopic methods and comparison with reported data. Compound 5 was reported for the first time from the title sponge. Compounds 4 and 5 concentration-dependently inhibited spontaneous synchronized Ca2+ oscillations (SCOs) and 4-aminopyridine (4-AP) -induced epileptic discharges in primary cultured cortical neuronal networks. Interestingly, compound 5 promoted SCOs at concentrations below 1 mu M and inhibited SCOs at concentrations above 3 mu M. The compound also inhibited 4-AP-induced SCOs' hyperactivity. This is the first report of steroid sulfates for their SCOs' inhibitory activity, showing potential as an antiepileptic agent. The chemotaxonomic significance of the isolated compounds was also discussed.

引用

页数：6

共 63 条

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