Metabolic reprogramming in lung cancer and its clinical implication

被引：4

作者：

Huang, Qingqiu ^{[1
]}

Fan, Lisha ^{[2
]}

Gong, Mingjing ^{[3
]}

Ren, Juntong ^{[4
]}

Chen, Chen ^{[5
]}

Xie, Shenglong ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Thorac Surg, Chengdu, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Pulm & Crit Care Med, Chengdu, Peoples R China

[3] First Vet Hosp Sichuan Prov, Sichuan Prov Revolutionary Disable Armyman Rehab, Chengdu, Peoples R China

[4] Guizhou Univ, Sch Pharmaceut Sci, Guiyang, Peoples R China

[5] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Outpatient, Chengdu, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

metabolic reprogramming; lung cancer; glucose; lipid metabolism; amino acid metabolism; FATTY-ACID SYNTHASE; GLUTAMINE-METABOLISM; THERAPEUTIC TARGET; GLUCOSE-METABOLISM; LIPID-METABOLISM; CELL METABOLISM; TUMOR; INHIBITION; ACTIVATION; GROWTH;

D O I：

10.3389/fphar.2024.1516650

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lung cancer has posed a significant challenge to global health, and related study has been a hot topic in oncology. This article focuses on metabolic reprogramming of lung cancer cells, a process to adapt to energy demands and biosynthetic needs, supporting the proliferation and development of tumor cells. In this study, the latest studies on lung cancer tumor metabolism were reviewed, including the impact of metabolic products and metabolic enzymes on the occurrence and development of lung cancer, as well as the progress in the field of lung cancer treatment targeting relevant metabolic pathways. This provides some promising potential directions into exploring lung cancer tumor metabolism and helps researchers to better understand lung cancer.

引用

页数：14

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