Three new diterpenoids from the aerial parts of Callicarpa macrophylla

被引：0

作者：

Gou, Liang ^{[1
,2
]}

Li, Rong-Shuai ^{[1
,2
,3
]}

Lai, Jian-Lin ^{[1
,2
]}

Ning, Yan-Mei ^{[1
,2
]}

Ji, Xue-Ting ^{[1
,2
]}

Qiu, Xiong ^{[1
,2
,3
]}

Peng, Chao ^{[1
,2
,3
]}

Li, Xiao-Li ^{[1
,2
]}

Zhang, Xing-Jie ^{[1
,2
]}

Xiao, Wei-Lie ^{[1
,2
,3
]}

机构：

[1] Yunnan Univ, Inst Int Rivers & Ecosecur, Sch Pharm, State Key Lab Conservat & Utilizat Bioresources Yu, Kunming, Peoples R China

[2] Yunnan Univ, Sch Chem Sci & Technol, Kunming, Peoples R China

[3] Southwest United Grad Sch, Kunming, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

基金：

中国国家自然科学基金;

关键词：

Callicarpa macrophylla Vahl; diterpenoids; structural elucidation; anti-inflammatory activity; LEAVES; STEMS;

D O I：

10.1080/14786419.2025.2505602

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three previously unreported diterpenoids, iso-gaultheric acid (1), 7 alpha-hydroxy-karamatsuic acid (2) and iso-bodinieric acid J (3), along with seven known diterpenoids (4-10), were yielded from the 95% ethanol extract of the aerial parts of Callicarpa macrophylla Vahl. The elucidation of their structure was accomplished through integrated interpretation of physicochemical characteristics combined with multi-spectral investigations, including 1D/2D NMR, ECD and HR-ESI-MS. Anti-inflammatory activity tests were conducted on the compounds 3-9, revealing that 6 inhibited LDH release with an IC50 value of 14.79 +/- 2.69 mu M.

引用

页数：7

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