Prevalence Rates and Outcomes of Hyponatremia in Patients with Crimean-Congo Hemorrhagic Fever

Background: In the study, we aimed to determine the prevalence rate of hyponatremia in patients with Crimean-Congo hemorrhagic fever (CCHF) and to investigate the relationship between hyponatremia and disease severity. Materials and Methods: Patients over 18 years of age who received a definitive diagnosis of CCHF between April 2018 and October 2023 were included in the study. The patients' sodium levels, symptoms, and findings at the time of admission to the hospital were recorded. In addition, the severity score index was calculated according to the laboratory values and findings at the time of admission. Results: The total number of patients included in the study was 219. Hyponatremia was detected at admission in 99 (45.2%) patients. The median serum sodium value in patients with hyponatremia was 133 (127-135) mEq/L. Spearman correlation analysis revealed a statistically significant inverse correlation between serum sodium level and severity score index (r = -0.522, p < 0.001). Conclusions: Mild hyponatremia was detected in almost half of the patients with CCHF, and this parameter may be useful in determining disease severity on admission.