IL-8 and IL-1β in the Cerebrospinal Fluid of Patient With Creutzfeldt-Jakob Disease: A Case Report

被引：0

作者：

Liu, Guoyan ^{[1
]}

Zhan, Shuqin ^{[1
]}

Qu, Huiyang ^{[1
]}

Chen, Mengying ^{[1
]}

Ren, Hongwei ^{[1
]}

Sun, Hong ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Med Sch, Dept Neurol, Xian, Shaanxi, Peoples R China

来源：

CLINICAL CASE REPORTS | 2025年 / 13卷 / 05期

关键词：

blood-brain barrier; cognitive impairment; Creutzfeldt-jakob disease; epileptic encephalopathy; IL-1; beta; IL-8; BLOOD-BRAIN-BARRIER; MICROGLIA; CYTOKINES;

D O I：

10.1002/ccr3.70508

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammatory cytokines play a crucial role in Creutzfeldt-jakob disease (CJD). We examined inflammatory cytokine levels in both blood and CSF in a CJD patient and an epileptic encephalopathy as a control case. Results showed that IL-6, IL-8, IL-1 beta, and TNF-alpha levels were elevated in blood, but only IL-8 and IL-1 beta levels, especially IL-8, were significantly elevated in Cerebrospinal fluid (CSF). This suggests that IL-8 and IL-1 beta are closely related to cognitive impairment and blood-brain barrier (BBB) damage in CJD, and IL-8 might be a key target in early cognitive impairment in CJD.

引用

页数：4

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