Association of the Triglyceride Glucose Index with Symptoms of Overactive Bladder in American Female Adults: A Cross-Sectional Study

Introduction and HypothesisTo investigate the potential correlation between the triglyceride-glucose (TyG) index and overactive bladder (OAB) symptoms within the female population.MethodsThis study used data from 7941 individuals obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2018 dataset. The following equation is used to calculate the TyG index: TyG = Ln [fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. The symptoms of OAB were based on individuals' self-reported comprehensive score. Weighted logistic regression models, encompassing both univariable and multivariable analyses, were employed to evaluate the relationship between the TyG index and OAB in women.ResultsAfter conducting extensive modifications, the multivariable logistic regression model revealed a significant correlation between the TyG index and mild OAB among American female adults (OR 1.36, 95% CI 1.09-1.70, P = 0.006). Upon categorizing the TyG index into 4 grades (Q1-Q4), a positive increase in OR values corresponding to higher TyG index grades can be observed.ConclusionsIn this study, our findings reveal a significantly positive relationship between elevated TyG index values and an increased prevalence of mild OAB among female adults. These findings suggest that metabolic dysregulation may drive early-stage OAB, while severe OAB symptoms may be more dependent on non-metabolic pathological changes. Further investigation is warranted to elucidate the underlying mechanisms in female adults.