Alkaloids from the Pleurotus tuoliensis and their anti-gastric cancer activity

被引：3

作者：

Li, Chunyi ^{[1
,2
]}

Shi, Leiling ^{[3
]}

Wang, Jijun ^{[4
]}

Ma, Guoxu ^{[3
,5
]}

Zhang, Wenbin ^{[6
]}

Li, Peng ^{[2
,6
]}

Zhang, Jing ^{[1
]}

机构：

[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun, Peoples R China

[2] Peoples Hosp Xinjiang Uygur Autonomous Reg, Gastrointestinal Surg Ctr, Gastrointestinal Surg Dept, Urumqi, Xinjiang, Peoples R China

[3] Xinjiang Inst Chinese & Ethn Med, Urumqi, Peoples R China

[4] Shaanxi Prov Peoples Hosp, Dept Rehabil Med, Xian, Peoples R China

[5] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing, Peoples R China

[6] Xinjiang Med Univ, Affiliated Tumor Hosp, Dept Gastrointestinal Surg, Urumqi, Xinjiang, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

关键词：

<italic>Pleurotus tuoliensis</italic>; alkaloids; antitumor; HGC-27; cells; HETEROCYCLIC-COMPOUNDS; CONSTITUENTS;

D O I：

10.1080/14786419.2025.2506781

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Eleven alkaloids (1-11) including four new ones tuoliensines A-D (1-4) were isolated from the fruiting body of Pleurotus tuoliensis using 95% ethanol heating reflux extraction. Their structures characterisation through chemical and spectral analyses classified these compounds as indole, pyridazine, and pyrrole alkaloids. The absolute constructions of the new compounds were identity by comparing computational and experimental electron circular dichroism (ECD) data. Furthermore, The antitumor activity of compounds 1-11 was analysed against HGC-27 cell line. The findings revealed that compound 5 had a significant inhibitory effect with an IC50 value of 1.93 mu M, which is superior to that of cisplatin (2.58 +/- 0.17 mu M). Additionally, compounds 1-4 displayed promising HGC-27 cell inhibition with IC50 values of 11.14, 8.53, 10.68, 3.89 mu M.

引用

页数：8

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