Role of Achyranthes aspera in neurodegenerative diseases: current evidence and future directions

被引：0

作者：

Luo, Huaiqing ^{[1
,2
]}

Wei, Siwen ^{[3
]}

Fu, Shujun ^{[1
,2
]}

Han, Li ^{[4
]}

机构：

[1] Hunan Normal Univ, Key Lab Model Anim & Stem Cell Biol Hunan Prov, Hlth Sci Ctr, Changsha, Hunan, Peoples R China

[2] Hunan Normal Univ, Inst Interdisciplinary Studies, Hlth Sci Ctr, Changsha, Hunan, Peoples R China

[3] Jishou Univ, Dept Immunol, Sch Med, Jishou, Hunan, Peoples R China

[4] Changsha Med Univ, Hunan Prov Key Lab New Pharmaceut Preparat, Changsha, Hunan, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2025年 / 16卷

基金：

中国国家自然科学基金;

关键词：

Achyranthes aspera; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease; Amyotrophic lateral sclerosis; neuroprotection; OLEANOLIC ACID; A-BETA; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; MEMORY IMPAIRMENT; OXIDATIVE STRESS; NEUROTOXICITY; MITOCHONDRIAL; HOMOCYSTEINE; CELLS;

D O I：

10.3389/fphar.2025.1511011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurodegenerative diseases are caused by the progressive degeneration of neurons and/or their myelin sheaths, ultimately leading to cognitive and motor dysfunction. Due to their complex pathogenesis and the limited efficacy of therapeutic drugs, these diseases have attracted significant attention. Achyranthes aspera, belongs to family Amaranthaceae, has been extensively used in the traditional and folk medicines for the treatment of various ailments. Modern research has revealed that Achyranthes aspera possesses various pharmacological effects, including cardiocerebrovascular protection, immune regulation, antioxidation, and anti-aging. Furthermore, the neuroprotective effects of Achyranthes aspera have been confirmed by numerous scientific studies. This review focuses on the primary pharmacological effects and mechanisms of Achyranthes aspera in the prevention and treatment of neurodegenerative diseases, as well as their potential application prospects. This review aims to provide insights into the potential clinical applications and research directions of Achyranthes aspera in neurodegenerative diseases.

引用

页数：13

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