Solubility Determination and Thermodynamic Modeling of Phenprobamate in 12 Pure Solvents from 283.15 to 323.15 K

被引：1
作者：
Qiu, Jingxuan [1 ,2 ,3 ]
Zhang, Rui [4 ]
Zhang, Chaoqun [1 ,2 ,3 ]
Lin, Jing [4 ]
Liu, Cong [4 ]
Guo, Yunchun [4 ]
Wang, Huiliang [4 ]
Xie, Yingxin [4 ]
Xiao, Ke [4 ]
机构：
[1] Jilin Engn Normal Univ, Inst Chem & Ind Bioengn, Changchun 130052, Peoples R China
[2] Jilin Engn Normal Univ, Sch Enterprise Joint Technol Innovat Lab, Novel Mol Funct Mat Jilin Prov, Changchun 130052, Jilin, Peoples R China
[3] Jilin Engn Normal Univ, Jilin Sci & Technol Innovat Ctr, Green Synth & New Mat Res & Dev, Changchun 130052, Jilin, Peoples R China
[4] Jilin Engn Normal Univ, Sch Biol & Food Engn, Changchun 130052, Jilin, Peoples R China
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2025年 / 70卷 / 06期
关键词：
ORGANIC-SOLVENTS; TEMPERATURE-RANGE; BINARY SOLVENTS; WATER; HYDROCHLORIDE; MIXTURES; EQUILIBRIUM; PARAMETERS; SYSTEMS; ACID;
D O I：
10.1021/acs.jced.5c00054
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
In this work, the solubility of phenprobamate in water, acetone, 2-butanone, methyl acetate, ethyl acetate, methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, and 1-pentanol was determined by a static gravimetric method at temperatures ranging from 283.15 to 323.15 K under atmospheric pressure. The solubility magnitudes increase monotonously with the increase of temperature in each solvent. The solubility is roughly ranked as propanone > methyl ethyl ketone > acetic acid methyl ester > ethyl acetate > water in non-alcohol solvents and methanol > 1-pentanol > sec-butanol > ethanol > n-butanol > n-propanol > isopropanol in alcohols. The solubility of phenprobamate could be ultimately determined by the combined influence of solvent polarity, hydrogen bond acceptor propensities, solvent-solvent intermolecular interactions, and spatial steric hindrance. In addition, the solubility data were correlated by the Apelblat model and the Yaws model. The outcomes show that the two models could both satisfactorily fit the experimental data, in which the Yaws model is more appropriate to correlate the solubility of phenprobamate compared with the Apelblat model. The data reported in this work contribute to the further crystallization and separation process of phenprobamate.
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页码：2494 / 2504
页数：11
相关论文
共 70 条
[1]   The rapid quantitative analysis of phenprobamate and acetaminophen by RP-LC and compensation technique [J].
Altun, ML ;
Erk, N .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2001, 25 (01) :85-92
[2]   Measurement and Correlation for Solubility of Moroxydine Hydrochloride in Pure and Binary Solvents [J].
An, Mengyao ;
Yi, Dengjing ;
Qu, Jingxuan ;
Liu, Haoyou ;
Hu, Shen ;
Han, Jiaming ;
Guo, Ying ;
Huang, Haishuang ;
He, Hui ;
Wang, Peng .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2020, 65 (05) :2611-2618
[3]   Measurement and Correlation for Solubility of L-Alanine in Pure and Binary Solvents at Temperatures from 283.15 to 323.15 K [J].
An, Mengyao ;
Qiu, Jingxuan ;
Yi, Dengjing ;
Liu, Haoyou ;
Hu, Shen ;
Han, Jiaming ;
Huang, Haishuang ;
He, Hui ;
Liu, Conglei ;
Zhao, Ziyi ;
Shi, Yan ;
Wang, Peng .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2020, 65 (02) :549-560
[4]   Solubilities of L-aspartic, DL-aspartic, DL-glutamic, p-hydroxybenzoic, o-anistic, p-anisic, and itaconic acids in water from T = 278 K to T = 345 K [J].
Apelblat, A ;
Manzurola, E .
JOURNAL OF CHEMICAL THERMODYNAMICS, 1997, 29 (12) :1527-1533
[5]   Solubilities of o-acetylsalicylic, 4-aminosalicylic, 3,5-dinitrosalicylic, and p-toluic acid, and magnesium-DL-aspartate in water from T = (278 to 348) K [J].
Apelblat, A ;
Manzurola, E .
JOURNAL OF CHEMICAL THERMODYNAMICS, 1999, 31 (01) :85-91
[6]  
Baker A. D. L., 2014, CLASS PAP ORTHOP, V8, P253, DOI [10.1007/978-1-4471-5451-862, DOI 10.1007/978-1-4471-5451-862]
[7]   Solubility measurement and modeling for the system propane-water from 277.62 to 368.16 K [J].
Chapoy, A ;
Mokraoui, S ;
Valtz, A ;
Richon, D ;
Mohammadi, AH ;
Tohidi, B .
FLUID PHASE EQUILIBRIA, 2004, 226 :213-220
[8]   THERMODYNAMIC STUDY OF PSYCHOTHERAPEUTIC SUBSTANCES .1. ANXIOLYTIC COMPOUNDS - PHENPROBAMATE, MEPROBAMATE, CLOBAZAM AND MEDAZEPAM [J].
CHAUVET, A ;
RUBIO, S ;
MASSE, J .
THERMOCHIMICA ACTA, 1982, 57 (02) :173-193
[9]   Protein purification with nanoparticle-enhanced crystallisation [J].
Chen, Wenqian ;
Cheng, Thomas N. H. ;
Khaw, Liang Fa ;
Li, Xiaoyu ;
Yang, Huaiyu ;
Ouyang, Jinbo ;
Heng, Jerry Y. Y. .
SEPARATION AND PURIFICATION TECHNOLOGY, 2021, 255
[10]   Determination and correlation of temperature andpHvalue dependent solubility ofdl-methionine [J].
Chen, Zhirong ;
Zhou, Rongfan ;
Yin, Hong ;
Yuan, Shenfeng .
AICHE JOURNAL, 2020, 66 (08)
1234567