Automatic volumetric temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MRg-LITT) with multiple laser probes

被引：0

作者：

Desclides, Manon ^{[1
,2
]}

Ozenne, Valéry ^{[1
]}

Bour, Pierre ^{[2
]}

Faller, Thibaut ^{[2
]}

Machinet, Guillaume ^{[3
]}

Pierre, Christophe ^{[3
]}

Carcreff, Julie ^{[3
]}

Chemouny, Stéphane ^{[2
]}

Quesson, Bruno ^{[1
]}

机构：

[1] University of Bordeaux, CNRS, CRMSB, UMR 5536, IHU Liryc, Bordeaux

[2] Certis Therapeutics, Pessac

[3] ALPhANOV, Talence

来源：

Computers in Biology and Medicine | 2025年 / 184卷

关键词：

LITT; MR-thermometry; Multiple laser probes; PID; Regulation; Thermotherapy;

D O I：

10.1016/j.compbiomed.2024.109445

中图分类号：

学科分类号：

摘要：

Background: Clinical Laser-Induced Thermotherapy (LITT) currently lacks precise control of tissue temperature increase during the procedure. This study presents a new method to automatically regulate the maximum temperature increase in vivo at different positions by adjusting LITT power delivered by multiple laser probes using real-time volumetric MR-thermometry. Methods: The regulation algorithm was evaluated in vivo on a pig leg muscle. Temperature regulation was performed in volumes surrounding each laser probe tip. The power delivered to each laser probe was automatically adjusted every second using a feedback control algorithm by processing on-the-fly MR-thermometry images (10 slices/second) on a 1.5 T clinical scanner (1.56 mm × 1.56 mm x 3 mm resolution), using the proton-resonance frequency (PRF) shift technique. Several experimental conditions were tested with predefined temperature-time profiles corresponding to conditions of thermal ablation (+30 °C above body temperature) or moderate hyperthermia (+10 and + 15 °C). Control images were acquired after injection of Gadolinium at the end of experiment and were compared with the thermal dose images calculated from the thermometry images. Results: The mean difference and root mean squared error between target temperatures and measured ones remained below 0.5 °C and 2 °C respectively, for 5 min duration. Lesion sizes observed on thermal dose and on images acquired after gadolinium injection were in good agreement. Conclusion: Automatic regulation of in vivo temperature increase during LITT procedures with multiple laser emitters control is feasible. The method provides an adaptative solution to improve the safety and efficacity of such clinical procedures. © 2024

引用

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