Multi-Omic Analysis Reveals the Potential Anti-Disease Mechanism of Disease-Resistant Grass Carp

被引：0

作者：

Wang, Chongqing ^{[1
,2
]}

Li, Zeyang ^{[1
]}

Huang, Xu ^{[1
]}

Xu, Xidan ^{[1
]}

Xu, Xiaowei ^{[1
]}

Zhang, Kun ^{[1
]}

Zhou, Yue ^{[1
]}

Bai, Jinhai ^{[1
]}

Liu, Zhengkun ^{[1
]}

Jiang, Yuchen ^{[1
]}

Tang, Yan ^{[1
]}

Deng, Xinyi ^{[1
]}

Li, Siyang ^{[1
]}

Hu, Enkui ^{[1
]}

Peng, Wanjing ^{[1
]}

Xiong, Ling ^{[1
]}

Xiao, Qian ^{[1
]}

Yang, Yuhan ^{[1
]}

Qin, Qinbo ^{[1
,2
]}

Liu, Shaojun ^{[1
]}

机构：

[1] Hunan Normal Univ, Coll Life Sci, Engn Res Ctr Polyploid Fish Reprod & Breeding, State Educ Minist, Changsha 410081, Peoples R China

[2] Nansha South China Agr Univ, Fishery Res Inst, Guangzhou 511457, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 08期

关键词：

gut-liver axis; disease-resistant grass carp; intestinal microflora; metabolites; transcriptome; GUT MICROBIOTA; HUMAN HEALTH; AQUACULTURE; SHAPE;

D O I：

10.3390/ijms26083619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gut-liver axis is essential in animal disease and health. However, the role of the gut-liver axis in the anti-disease mechanism of disease-resistant grass carp (DRGC) derived from the backcross of female gynogenetic grass carp (GGC) and male grass carp (GC) remains unclear. This study analyzed the changes in gut histopathology, fecal intestinal microflora and metabolites, and liver transcriptome between GC and DRGC. Histological analysis revealed significant differences in the gut between DRGC and GC. In addition, microbial community analyses indicated that hybridization induced gut microbiome variation by significantly increasing the proportion of Firmicutes and Bacteroidota in DRGC. Metabolomic data revealed that the hybridization-induced metabolic change was probably characterized by being related to taurocholate and sphinganine in DRGC. Transcriptome analysis suggested that the enhanced disease resistance of DRGC was primarily attributed to immune-related genes (SHMT2, GOT1, ACACA, DLAT, GPIA, TALDO1, G6PD, and FASN). Spearman's correlation analysis revealed a significant association between the gut microbiota, immune-related genes, and metabolites. Collectively, the gut-liver axis, through the interconnected microbiome-metabolite-gene pathway, may play a crucial role in the mechanism of greater disease resistance in DRGC, offering valuable insights for advancing the grass carp cultivation industry.

引用

页数：17

共 73 条

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