Preparation of astaxanthin liposomes using supercritical carbon dioxide

被引：0

作者：

Liu, Zhijun ^{[1
]}

Liu, Qian ^{[1
]}

Wang, Ronghao ^{[1
]}

Li, Zhiyi ^{[1
]}

Liu, Fengxia ^{[1
]}

Wei, Wei ^{[1
]}

机构：

[1] R&D Institute of Fluid and Powder Engineering, Dalian University of Technology, Liaoning, Dalian

来源：

Jingxi Huagong/Fine Chemicals | 2025年 / 42卷 / 04期

关键词：

astaxanthin; drug materials; encapsulation efficiency; liposomes; particle size; supercritical carbon dioxide;

D O I：

10.13550/j.jxhg.20240216

中图分类号：

学科分类号：

摘要：

Astaxanthin liposomes were prepared using supercritical carbon dioxide with soya lecithin as lipid carrier, and characterized by FTIR, TEM and XRD. The effects of preparation pressure and temperature on particle size distribution, Zeta potential and astaxanthin encapsulation rate of astaxanthin liposomes were analyzed via nanometer particle size and Zeta potential analyzer as well as UV-visible spectrophotometer. The sustained release performance of astaxanthin liposomes was evaluated through in vitro simulated release and simulated digestion experiments. The results demonstrated that under the optimal conditions of supercritical carbon dioxide pressure of 20 MPa and 50 ℃, the prepared astaxanthin liposomes showed an average particle size of 236.0 nm, and an astaxanthin encapsulation rate of 97.18%. After 30 d storage, the astaxanthin retention rate of astaxanthin liposomes at 4 and 25 ℃ was 94.13% and 89.04%, respectively. In vitro release experiments demonstrated that the astaxanthin liposomes exhibited excellent slow-release effect, with total release rates of 69.3% and 91.0% at 4 and 12 h, respectively. In vitro digestion simulations indicated that the astaxanthin liposomes exhibited enhanced digestion and absorption in the intestine. © 2025 Fine Chemicals. All rights reserved.

引用

页码：872 / 877and917

共 40 条

[1]

LI H M, GAO L, Astaxanthin: Chemical structure, biological functions and usage, Fine Chemicals, 20, 1, pp. 32-37, (2003)

[2]

NAGUIB Y M A., Antioxidant activities of astaxanthin and related carotenoids, Journal of Agricultural and Food Chemistry, 48, 4, pp. 1150-1154, (2000)

[3]

ZHOU Q X, YANG L, XU J, Et al., Evaluation of the physicochemical stability and digestibility of microencapsulated esterified astaxanthins using in vitro and in vivo models, Food Chemistry, 260, pp. 73-81, (2018)

[4]

MONTERO P, CALVO M M, GOMEZ-GUILLEN M C, Et al., Microcapsules containing astaxanthin from shrimp waste as potential food coloring and functional ingredient: Characterization, stability, and bioaccessibility, LWT-Food Science & Technology, 70, pp. 229-236, (2016)

[5]

KRAFT J C, FREELING J P, WANG Z Y, Et al., Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems, Journal of Pharmaceutical Sciences, 103, 1, pp. 29-52, (2014)

[6]

SUN J Y, LU L J, LU L X, Et al., Preparation of responsive controlled-release antioxidant composite film based on temperature-sensitive liposomes of rosemary essential oil, Fine Chemicals (精细化工), 38, 8, pp. 1564-1569, (2021)

[7]

YAN S, FAN J, TAN C L, Preparation of collagenic liposome and its percolation through skin, Fine Chemicals, 29, 6, pp. 576-579, (2012)

[8]

TAKAHASHI M, UECHI S, TAKARA K, Et al., Evaluation of an oral carrier system in rats: Bioavailability and antioxidant properties of liposome-encapsulated curcumin, Journal of Agricultural and Food Chemistry, 57, 19, pp. 9141-9146, (2009)

[9]

ISAILOVIC B D, KOSTIC I T, ZVONAR A, Et al., Resveratrol loaded liposomes produced by different techniques, Innovative Food Science & Emerging Technologies, 19, pp. 181-189, (2013)

[10]

LIU D, HU H Y, LIN Z X, Et al., Quercetin deformable liposome: Preparation and efficacy against ultraviolet B induced skin damages in vitro and in vivo, Journal of Photochemistry and Photobiology B: Biology, 127, pp. 8-17, (2013)

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