Sustainable Synthesis of 3-Acylmethylated Coumarins via Photoredox Catalytic Radical Addition/Cyclization in Aqueous Media

被引：0
作者：
Zhu, Binfeng [1 ]
Ponnam, Devendar [1 ]
Li, Mingzhu [1 ]
Li, Guokai [1 ]
Fan, Ruifeng [1 ,2 ]
Chen, Jingchao [1 ,2 ]
Fan, Baomin [1 ,2 ]
机构：
[1] Yunnan Minzu Univ, Yunnan Key Lab Chiral Funct Subst Res & Applicat, Kunming 650504, Peoples R China
[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650500, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 23期
基金：
中国国家自然科学基金;
关键词：
ORGANIC-REACTIONS; ANTIINFLAMMATORY ACTIVITY; ARYL ALKYNOATES; BOND FORMATIONS; CYCLIZATION; WATER; CHEMISTRY; PHENOLS; DESIGN; ACCELERATION;
D O I：
10.1021/acs.joc.5c00608
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A photoredox catalytic cascade radical reaction for the addition/cyclization of arylalkynoates with alpha-bromoketones in water at room temperature has been developed, offering a green and efficient approach for synthesizing 3-acylmethylated coumarins. This method eliminates the need for conventional organic solvents, phase-transfer catalysts, and excess oxidants, ensuring operational simplicity and environmental sustainability. The reaction is scalable, accommodates a broad array of substrates with outstanding tolerance for functional groups, and offers a versatile route to biologically valuable coumarins.
引用
收藏
页码：7738 / 7745
页数：8
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