PREFERENTIAL SOLVATION OF DIFENOCONAZOLE IN BINARY SOLVENT MIXTURES OF METHANOL AND ETHANOL IN WATER AT SEVERAL TEMPERATURES

The present investigation used the inverse Kirkwood-Buff integrals technique to determine the best solvation parameters delta x(1,DIF) for DIF in two distinct alcoholic aqueous solutions, spanning a temperature range from 293.15 K to 323.15 K. The analysis demonstrated that the values of delta x(1,DIF) displayed a nonlinear trend concerning the composition of the co-solvent. The solvation parameters (delta x(1,DIF)) for DIF in various aqueous solutions revealed nonlinear variations that were contingent upon the concentration of the co-solvent. Notably, positive values were recorded in mixtures with all compositions for methanol and 0.00 < x(1 )< 0.33-0.35 and 0.50 < x(1 )< 1.00 for ethanol. Conversely, DIF demonstrates a preference for alcohol as the solvent in aqueous mixtures. At 323.15 K, the methanol (1) + water (2) mixtures show the highest preferential solvation of DIF by alcohol, while the ethanol (1) + water (2) mixtures exhibit the lowest.