Prevalence and Significance of Pancreatic Iron in Transfusion-Dependent Sickle Cell Disease

被引：0

作者：

Vadivelan, Akhila ^{[1
]}

Doyle, Eamon ^{[2
]}

Carson, Susan ^{[3
]}

Denton, Christopher ^{[3
]}

Veluswamy, Saranya ^{[3
]}

Hofstra, Thomas ^{[3
]}

Coates, Thomas ^{[3
]}

Wood, John C. ^{[4
]}

机构：

[1] UCLA Mattel Childrens Hosp, Dept Pediat, Div Pediat Hematol Oncol, Los Angeles, CA USA

[2] USC Keck Sch Med, Childrens Hosp Los Angeles, Dept Clin Radiol, Los Angeles, CA USA

[3] USC Keck Sch Med, Childrens Hosp Los Angeles, Canc & Blood Dis Inst, Sect Hematol,Dept Pediat, Los Angeles, CA USA

[4] USC Keck Sch Med, Childrens Hosp Los Angeles, Dept Pediat, Div Cardiol, Los Angeles, CA 90033 USA

来源：

PEDIATRIC BLOOD & CANCER | 2025年 / 72卷 / 08期

关键词：

pancreatic siderosis; sickle cell disease; transfusion dependent; OVERLOAD; GLUCOSE;

D O I：

10.1002/pbc.31780

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundChronically transfused patients with sickle cell disease (SCD) and beta thalassemia major (TM) develop iron overload.ObjectiveDetermine the impact of iron overload on glucose regulation in SCD.MethodsProspective study of 28 patients with SCD and 38 patients with TM who underwent liver and pancreas R2* measurements and oral glucose tolerance tests.ResultsImpaired fasting glucose (2 vs. 9, p = 0.27) and impaired glucose tolerance (1 vs. 11, p = 0.019) were less common in patients with SCD compared with patients with TM. No SCD patient had diabetes.ConclusionIron-mediated glucose dysregulation is present but less common in SCD patients.

引用

页数：4

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