Facile One-Pot Fischer-Suzuki-Knoevenagel Microwave-Assisted Synthesis of Fluorescent 5-Aryl-2-Styryl-3H-Indoles

被引：0

作者：

Bartkus, Martynas Rojus ^{[1
]}

Kleiziene, Neringa ^{[2
]}

Bieliauskas, Aurimas ^{[2
]}

Sackus, Algirdas ^{[1
,2
]}

机构：

[1] Kaunas Univ Technol, Dept Organ Chem, Radvilenu Pl 19, LT-50254 Kaunas, Lithuania

[2] Kaunas Univ Technol, Inst Synthet Chem, K Barsausko G 59, LT-51423 Kaunas, Lithuania

来源：

MOLECULES | 2025年 / 30卷 / 12期

关键词：

one-pot synthesis; consecutive multicomponent reaction; microwave synthesis; Fischer synthesis; Suzuki cross-coupling reaction; Knoevenagel condensation; 2-styryl-3H-indole; fluorescence; HETEROCYCLIC-COMPOUNDS; STYRYL-LACTONES; DNA-BINDING; DERIVATIVES; ANALOGS; SALTS;

D O I：

10.3390/molecules30122503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, novel fluorescent 5-aryl-2-styryl-3H-indole derivatives were efficiently synthesized from 4-bromophenylhydrazine hydrochloride using the microwave-accelerated one-pot technique, which includes Fischer synthesis, Suzuki cross-coupling, and Knoevenagel condensation. The structural assignments of the synthesized compounds were based on 1H, 13C, 15N, and 19F NMR; IR spectroscopy; and HRMS spectral data. The optical properties of the newly obtained styryl-indole dyes were studied using UV-vis and fluorescence spectroscopy, which clearly demonstrated that the derivatives substituted with electron-donating or -withdrawing groups exhibited varying emission shifts and quantum yields ranging from negligible to high.

引用

页数：26

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