Pro-inflammatory Cytokines, Ferroptosis, and Cancer

被引：0

作者：

Vartanian, A. A. ^{[1
]}

Kosorukov, V. S. ^{[1
]}

机构：

[1] Minist Hlth Russia, NN Blokhin Natl Med Res Ctr Oncol, Moscow 115478, Russia

来源：

ACTA NATURAE | 2025年 / 17卷 / 01期

关键词：

ferroptosis; intratumoral immunosuppression; pro-inflamatory cytokines; cancer; TUMOR INVASIVENESS; IRON HOMEOSTASIS; KAPPA-B; INTERLEUKIN-6; METABOLISM; IL-1; FIBROBLASTS; PROGRESSION; CELLS;

D O I：

10.32607/actanaturae.27547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis, iron-dependent regulated cell death, is induced by the polyunsaturated fatty acid peroxidation of membrane phospholipids and is controlled by glutathione peroxidase 4. In recent years, convincing evidence has emerged, demonstrating a close relationship between chemo-, radio-, immuno-, and targeted therapy resistance and ferroptosis resistance. In this review, we discuss the basic principles of ferroptosis in cancer. Considerable attention is paid to the formation of an immunosuppressive tumor microenvironment. The main focus is centered on the involvement of the excessive, chronic production of pro-inflammatory cytokines in ferroptosis resistance development in tumors.

引用

页码：4 / 10

页数：7

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